Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06572332
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-25
Brief Title:
Simulation-informed Modelling and Personalized Evaluation SIMPLE in Ageing Populations
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Simulation-informed Modelling and Personalized Evaluation SIMPLE A Computational Study of MRI-based Brain Age Matrices
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SIMPLE
Brief Summary:
Multimodal magnetic resonance imaging MRI detecting brain structural and functional changes has emerged as a powerful and promising technique to study individuals brain as T1-weighted scans can detect morphometric features diffusion tensor imaging DTI scans can quantify structural connectivity and functional MRI can capture the features of functional connectivity Notably with the advances in quantitative methods computational models of brain age and brain-predicted age difference brain-PAD detecting the ageing effects on individuals brain features are becoming increasingly popular in clinical studies which might revolutionize the diagnostic and prognostic phonotypes of age-related brain diseases globally
Detailed Description:
The score of brain-PAD has threefold explanations a negative score representing decelerated brain ageing brain agechronological age b positive score representing accelerated brain ageing brain agechronological age c score equal to zero representing normal brain ageing brain agechronological age The score of brain-PAD indicates the brain ageing pattern with the interaction of lifestyle and cognitive status at individual level For example based on structural MRI scans a younger brain age or a negative score of brain-PAD was found to be associated with better cognition which indicates the potential utilities of brain age matrices in predicting individuals cognitive maintenance and healthy longevity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None