Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005471
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Anxiety and Cardiovascular Autonomic Control
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the hypothesis that chronic anxiety andor anxiety disorders resulted in hyperkinetic cardiovascular autonomic regulation often associated with increased coronary risk
Detailed Description:
BACKGROUND
Prospective epidemiologic data indicate a strong relationship of chronic anxiety andor anxiety disorders to risk of sudden cardiac death Other studies have shown that cardiac autonomic mechanisms are altered among stably anxious individuals in the direction of reduced parasympathetic and elevated sympathetic control The latter investigations however have been based on very small clinic samples and have been incomplete in their assessment of cardiovascular regulation in anxiety
This investigation was the first large-scale population-based research examining the cardiovascular physiology of anxiety and helped to increase understanding of the reported association between anxiety and sudden cardiac death This study also helped to identify groups in the general population at increased risk of sudden death
DESIGN NARRATIVE
The study used an ongoing well-characterized cohort the VA Normative Aging Study NAS to recruit middle-aged and older community-dwelling men and women into the study Using a variety of validated psychological and psychiatric screening instruments--including the Brief Symptom Inventory the Composite International Diagnostic Interview the Spielberger State-Trait Anxiety Inventory and the Crown-Crisp Index--the study population was characterized in terms of symptoms of anxiety and diagnosis of anxiety disorders Cardiovascular autonomic control was then assessed among anxious and non-anxious individuals using non-invasive time-domain and power-spectral measures of heart rate and blood pressure variability Cardiac output total peripheral resistance and end-tidal pCO2 were simultaneously assessed
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Prospective epidemiologic data indicate a strong relationship of chronic anxiety andor anxiety disorders to risk of sudden cardiac death Other studies have shown that cardiac autonomic mechanisms are altered among stably anxious individuals in the direction of reduced parasympathetic and elevated sympathetic control The latter investigations however have been based on very small clinic samples and have been incomplete in their assessment of cardiovascular regulation in anxiety
This investigation was the first large-scale population-based research examining the cardiovascular physiology of anxiety and helped to increase understanding of the reported association between anxiety and sudden cardiac death This study also helped to identify groups in the general population at increased risk of sudden death
DESIGN NARRATIVE
The study used an ongoing well-characterized cohort the VA Normative Aging Study NAS to recruit middle-aged and older community-dwelling men and women into the study Using a variety of validated psychological and psychiatric screening instruments--including the Brief Symptom Inventory the Composite International Diagnostic Interview the Spielberger State-Trait Anxiety Inventory and the Crown-Crisp Index--the study population was characterized in terms of symptoms of anxiety and diagnosis of anxiety disorders Cardiovascular autonomic control was then assessed among anxious and non-anxious individuals using non-invasive time-domain and power-spectral measures of heart rate and blood pressure variability Cardiac output total peripheral resistance and end-tidal pCO2 were simultaneously assessed
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL054098 | NIH | None | httpsreporternihgovquickSearchR01HL054098 |