Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06572995
Status:
RECRUITING
Last Update Posted:
None
First Post:
2023-04-24
Brief Title:
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment of Intra-thoracic Water by Bio Reactance During Stabilization and Therapeutic De-escalation in Septic Shock A Prospective Multicenter Observational Study
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TFC-SEPSIS
Brief Summary:
In ICU fluid challenge represents one of the cornerstones of hemodynamic care However fluid overload due to an excessive andor inappropriate fluid administration could be associated with morbidity or mortality Unfortunately there is currently no continuous non-invasive devices to monitor fluid content at bedside Bio reactance is a non-invasive rapid and continuous technology developed in order to measure body fluid compartment Monitoring devices functioning with such technology are promising to evaluate fluid overload in ICU
Detailed Description:
During the resuscitation phase of shock fluid administration represents one of the cornerstones of care in order to increase cardiac output and improve microvascular blood flow However inappropriate fluid administration can increase tissue edema which compromises recovery after the resolution of shock state Recently Sakr et al demonstrated that a higher fluid balance at 72 hours was associated with hospital mortality after septic shock Furthermore an administration of more than 5 liters of fluid during the first ICU stay was independently associated with an increase in mortality and hospital costs Therefore treating fluid removal appears to be a key component of the de-escalation phase of shock Thus all valuable parameters which potentially reflect tissue edema may help clinicians to individualized the necessity of fluid removal during the stabilization and de-escalation phase of shock Among them extra-vascular lung water EVLW measured with trans-pulmonary thermodilution is able to detect changes in thoracic fluid content but needs to be monitored invasively and only sequential values are recorded each thermodilution measure On the other hand lung ultrasonography may help clinicians to assess fluid overload but its ability to quantify thoracic fluid content is difficult and subjective
Bio reactance is a non-invasive rapid and continuous method to measure body fluid compartment All measures can be performed at bedside Bio reactance monitoring devices allow measurement of hemodynamic parameters such as cardiac index or stroke volume but also Thoracic Fluid Content TFC TFC is measured through the changes in impedance of thoracic tissue to the electrical current This parameter represents the whole fluid content in the thorax intravascular extravascular and intra-pleural TFC has already been evaluated in several context During hemodialysis TFC is correlated to the amount of fluid removal and might help clinician to improve hemodialysis session management in ICU In cardiac surgery electrical impedance is correlated with changes in fluid balance In ICU TFC is able to predict a mechanical ventilation weaning failure with a moderate accuracy AUC 069 057 - 08 bet cut-off value 50 kΩ-1 in patients with moderate to severe alteration of left ventricular ejection fraction
The main objective of the current study will evaluated correlation between thoracic fluid content TFC measurement and other valuable indices of fluid overload used at bedside Secondary objectives will be to evaluate association between TFC and other clinical outcomes organ dysfunction mortality and quality of life after hospital living
Bio reactance is a non-invasive rapid and continuous method to measure body fluid compartment All measures can be performed at bedside Bio reactance monitoring devices allow measurement of hemodynamic parameters such as cardiac index or stroke volume but also Thoracic Fluid Content TFC TFC is measured through the changes in impedance of thoracic tissue to the electrical current This parameter represents the whole fluid content in the thorax intravascular extravascular and intra-pleural TFC has already been evaluated in several context During hemodialysis TFC is correlated to the amount of fluid removal and might help clinician to improve hemodialysis session management in ICU In cardiac surgery electrical impedance is correlated with changes in fluid balance In ICU TFC is able to predict a mechanical ventilation weaning failure with a moderate accuracy AUC 069 057 - 08 bet cut-off value 50 kΩ-1 in patients with moderate to severe alteration of left ventricular ejection fraction
The main objective of the current study will evaluated correlation between thoracic fluid content TFC measurement and other valuable indices of fluid overload used at bedside Secondary objectives will be to evaluate association between TFC and other clinical outcomes organ dysfunction mortality and quality of life after hospital living
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None