Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06576505
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-12
Brief Title:
Immunological Mechanisms in Sarcoidosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Immunologiska Mekanismer Vid Sarkoidos
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is no cure for the inflammatory disease sarcoidosis Virtually any part of the body can be affected but most often the lungs and lymph nodes Outcomes after diagnosis vary widely among sarcoidosis patients with some experiencing resolving disease and others developing chronic disease and lung fibrosis Cardiac sarcoidosis can lead to life threatening arrythmias and calcium metabolism disturbances can lead to renal impairment
Treatment with different forms of immunosuppressants are usually tried to dampen symptoms but are not effective in all patients Furthermore the disease usually flares up after cessation of treatment The variability in diseae course and treatment response is thought at least to some degree to be explained by individual differences in genetics immune cells and signaling pathways But existing evidence is limited In other inflammatory diseases the gut microbiome is of importance for disease course but its role in sarcoidosis has not been clarified
In this prospective project the investigators will study genes inflammatory cells and signaling molecules in the lung upper airways and blood and to some extent microbes also in faeces Healthy volunteers will be included for comparative studies Most samples will be taken during normal diagnostic work-up and follow-up of patients withwith suspected sarcoidosis The findings will be correlated to disease course and effects of different treatments By linking to national health data and demographic registries comorbidities and environmental factors will be correlated to data
By this the investigators hope to improve understanding of which genes cells and signaling molecules that are of importance for resolving vs non-resolving disease and why some patients respond to a certain treatment and others dont The overall goal is to assess and predict sarcoidosis outcomes We hypothesize that blood-based biomarkers including those taken during routine care as well as novel cell signaling molecules and genetic markers in combination with clinical characteristics can be used to predict outcomes also treatment response in sarcoidosis The results can lead to tailored treatment and individual follow-up for each patient with sarcoidosis
Treatment with different forms of immunosuppressants are usually tried to dampen symptoms but are not effective in all patients Furthermore the disease usually flares up after cessation of treatment The variability in diseae course and treatment response is thought at least to some degree to be explained by individual differences in genetics immune cells and signaling pathways But existing evidence is limited In other inflammatory diseases the gut microbiome is of importance for disease course but its role in sarcoidosis has not been clarified
In this prospective project the investigators will study genes inflammatory cells and signaling molecules in the lung upper airways and blood and to some extent microbes also in faeces Healthy volunteers will be included for comparative studies Most samples will be taken during normal diagnostic work-up and follow-up of patients withwith suspected sarcoidosis The findings will be correlated to disease course and effects of different treatments By linking to national health data and demographic registries comorbidities and environmental factors will be correlated to data
By this the investigators hope to improve understanding of which genes cells and signaling molecules that are of importance for resolving vs non-resolving disease and why some patients respond to a certain treatment and others dont The overall goal is to assess and predict sarcoidosis outcomes We hypothesize that blood-based biomarkers including those taken during routine care as well as novel cell signaling molecules and genetic markers in combination with clinical characteristics can be used to predict outcomes also treatment response in sarcoidosis The results can lead to tailored treatment and individual follow-up for each patient with sarcoidosis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None