Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06578832
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-25
Brief Title:
Assessment of The Oral Health Status of Children With Chronic Kidney Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment of The Oral Health Status of Children With Chronic Kidney Disease
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to compare the oral health findings salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney DiseaseCKD those undergoing dialysis and transplantation with healthy children and to evaluate certain serum biomarkers in children with CKD
Detailed Description:
Chronic kidney disease CKD is a progressive and irreversible decline in the function of many nephrons and glomerular filtration rate due to kidney diseases This decline leads to increased serum levels of urea and creatinine Patients with CKD often exhibit various oral manifestations such as an ammonia-like odor gingival enlargement due to drug therapy enamel hypoplasia dental calculus dry mouth uremic stomatitis and oral mucosal lesions Interestingly children with CKD tend to have a lower prevalence of dental caries likely due to the high urea content in their saliva which has antibacterial properties CKD is also associated with salivary gland dysfunction and increased oxidative damage Furthermore CKD patients have reduced bone quality making them more susceptible to fractures A study on the quality of life QoL in children with CKD and their parents reported significantly lower physical and social QoL scores in children undergoing hemodialysis compared to healthy controls This study aims to comparatively evaluate and analyze children diagnosed with different stages of chronic kidney disease CKD and healthy children without any systemic conditions focusing on their age gender and oral health habits such as tooth brushing frequency dental floss usage and annual dentist visits Disease-related information such as the stage of CKD dialysis and transplantation as well as oral findings will be examined using DMFTdft ICDAS II DDE BAKH DI CI OHI-S and MGI indices The study will assess general disease-related quality of life from both the childs and the parents perspectives using the KINDLR scale Additionally salivary samples collected from children with CKD and healthy children will be analyzed for salivary flow rate pH buffering capacity total oxidant and antioxidant capacities urea calcium potassium and phosphorus levels Serum urea calcium and phosphorus values will also be examined
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None