Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06579651
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-29
Brief Title:
Nailfold Capillaroscopic Pattern Changes and Its Correlation with Interstitial Lung Disease ILD in Systemic Sclerosis SSc Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Nailfold Capillaroscopic Pattern Changes and Its Correlation with Interstitial Lung Disease ILD in Systemic Sclerosis SSc Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Detection of different pattern of nail fold capillary changes in SSc patients Correlation of nail fold capillary changes in SSc patients with ILD
Detailed Description:
SSc is a connective tissue disease characterized by early microvascular damage and dysfunction and immune system activation as well as progressive fibrosis in the skin and internal organs
Nailfold videocapillaroscopy NVC is the validated technique to assess SSc microvascular damage and is useful for the early diagnosis and follow-up of SSc micro- angiopathy
Several studies have demonstrated correlations between microvascular damage extent and the severity of internal organ involvement showing that NVC abnormalities correlate with disease activity and severity and may be also predictive for disease worsening Furthermore successful treatments have been shown to reduce NVC abnormalities in SSc cases and these findings support the importance of NVC in monitoring SSc patients and also suggest its possible role as an outcome measure for microangiopathy in clinical trials
Three different NVC patterns of microvascular damage have been described 34early34 34active34 34late34
Nailfold videocapillaroscopy NVC is the validated technique to assess SSc microvascular damage and is useful for the early diagnosis and follow-up of SSc micro- angiopathy
Several studies have demonstrated correlations between microvascular damage extent and the severity of internal organ involvement showing that NVC abnormalities correlate with disease activity and severity and may be also predictive for disease worsening Furthermore successful treatments have been shown to reduce NVC abnormalities in SSc cases and these findings support the importance of NVC in monitoring SSc patients and also suggest its possible role as an outcome measure for microangiopathy in clinical trials
Three different NVC patterns of microvascular damage have been described 34early34 34active34 34late34
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None