Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06582680
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-30
Brief Title:
Aging Beta Blockers and Thermoregulatory Responses
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Aging Beta Blockers and Thermoregulatory Responses
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults
Detailed Description:
Older individuals are more likely to die or become ill during heat waves During the 1995 Chicago heat wave there was 35 increase in hospital admissions for individuals older than 65 years of age Moreover adults over the age of 65 have a heat-related death rate that is more than double any other age group Therefore with an increasing elderly population that is expected to rise by 60 to 78 million by 2035 the causes of this excess mortality must be understood to better protect the ageing United States population It is notable that selective and non-selective beta blocker drugs are commonly prescribed to older individuals with cardiovascular diseases In younger individuals exposed to a heat stress beta blocker administration reduced whole-body sweat rate and skin blood flow responses resulting in greater increases in core body temperature Notably nothing is known regarding the effects of beta blockers on thermoregulatory responses during heat exposure in older individuals
This project will evaluate core body temperature responses to selective and non-selective beta blocker drugs during simulated heat wave exposure in older individuals
This project will evaluate core body temperature responses to selective and non-selective beta blocker drugs during simulated heat wave exposure in older individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None