Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06582914
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-30
Brief Title:
Lynch Syndrome Integrative Epidemiology and Genetics
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Lynch Syndrome Integrative Epidemiology and Genetics LINEAGE
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LINEAGE
Brief Summary:
The vision of the Lynch syndrome INtegrative Epidemiology And GEnetics LINEAGE Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome
The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research This consortium will provide intellectual and infrastructure support to facilitate development of research questions collection of standardized data and biospecimens support of grant applications and generation of collaborative manuscripts
Our aims are to
I Establish a prospective cohort of individuals with Lynch syndrome II Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome
The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research This consortium will provide intellectual and infrastructure support to facilitate development of research questions collection of standardized data and biospecimens support of grant applications and generation of collaborative manuscripts
Our aims are to
I Establish a prospective cohort of individuals with Lynch syndrome II Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome
Detailed Description:
The main objective of this consortium is to build a shared resource to drive research in critical areas necessary to understand LS-related neoplasia risk and improve early detection and prevention of LS-associated cancers This consortium will provide intellectual and infrastructure support to facilitate development of research questions collection of standardized clinical data and biospecimens support grant applications and generate collaborative manuscripts
Data and samples collected for LINEAGE will allow the consortium to address a variety of topic areas including but not limited to
I Risk of prevalent and incident colorectal neoplasia among PVLPV carriers II Estimate risk of prevalent and incident extra-colonic neoplasm among PVLPV carriers
III Characterization of post-colonoscopy colorectal cancer among PVLPV carriers
IV Risk factors for prevalent and incident neoplasia
The LINEAGE Consortium is an observational prospective cohort study with baseline and annual electronic health record EHR abstraction and electronic participant and provider surveys The consortium may also collect single or serial biosamples from identified and enrolled LS patients at participating centers
Data and samples collected for LINEAGE will allow the consortium to address a variety of topic areas including but not limited to
I Risk of prevalent and incident colorectal neoplasia among PVLPV carriers II Estimate risk of prevalent and incident extra-colonic neoplasm among PVLPV carriers
III Characterization of post-colonoscopy colorectal cancer among PVLPV carriers
IV Risk factors for prevalent and incident neoplasia
The LINEAGE Consortium is an observational prospective cohort study with baseline and annual electronic health record EHR abstraction and electronic participant and provider surveys The consortium may also collect single or serial biosamples from identified and enrolled LS patients at participating centers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None