Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06583421
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-22
Brief Title:
Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sharp increase in childhood obesity has been regarded as one of the most serious but preventable global public health challenges Engaging children in moderate-to-vigorous physical activity MVPA is important to address the obesity problem as it is associated with a host of obesity outcomes including body weight BMI body fat percentage waist circumference lean body mass systolic blood pressure insulin sensitivity cardiovascular health and cognitive development In China only about one-third of children meet the recommended guidelines of at least 60 minutes of MVPA per day and obesity rates are rising
Children with different generic characteristics may benefit differently from MVPA which should not be neglected when conducting interventions among children However most of the evidence about how genes interact with MVPA on obesity among children were addressed from cross-sectional design or synthetic lifestyle interventions Change-on-change analysis was used in our study based on a randomized controlled trial of MVPA intervention to discusses the effect of genetics and physical activity on obesity indicators In addition investigators used Generic risk scores GRSs based on 14 BMI-associated SNPs to assess generic variation of Chinese children
Children with different generic characteristics may benefit differently from MVPA which should not be neglected when conducting interventions among children However most of the evidence about how genes interact with MVPA on obesity among children were addressed from cross-sectional design or synthetic lifestyle interventions Change-on-change analysis was used in our study based on a randomized controlled trial of MVPA intervention to discusses the effect of genetics and physical activity on obesity indicators In addition investigators used Generic risk scores GRSs based on 14 BMI-associated SNPs to assess generic variation of Chinese children
Detailed Description:
This study is based on a randomized controlled trial of a 4-week MVPA intervention PASS 110 software was used to calculate the sample size of the randomized controlled trial study quantitative variable Investigators recruited obese children aged 10-12 years according to the criteria for overweight and obesity in Chinese children and adolescents proposed by the Working Group on Obesity in China WGOC Children with physical activity-limiting diseases and obesity due to diseases were excluded
The 4-week MVPA intervention engaged in supervised aerobic exercise resistance training and interesting sport for 60 minutes 3 daysweek Monday Wednesday and Friday No physical activity interventions were conducted in the control group In order to safeguard the rights of the control groups the same physical activity intervention was given to the control group at the end of the research
Physical activity strength was measured by Tri-axial body motion recorder ActiGraph Wgt3x-BT USA to maintain relative intensity At baseline Physical Activity Questionnaire for Children PAQ-C was answered by each participant
Height was measured to the nearest 01cm using Height Measuring Ruler Selcom Germany Body weight and fat mass was measured to the nearest 01kg using Body Composition Analyzer DC-13 Parade JapanWaist circumference and hip circumferencewas measured to the nearest 01cm with measuring tape
Preperitoneal fat and abdominal subcutaneous fat thickness were measured by ultrasonography The thickness and area of preperitoneal fat and abdominal subcutaneous fat were measured with a linear array probe L12-5 38 mm 5-12 HZ according to the method of Suzuki
The whole genomic DNA of blood mononuclear cells was performed using a fully automated nucleic acid extractor QIAGEN QIAcube Germany the DNA extraction reagents were used in a magnetic bead method DNA extraction kit QIAGEN 51331 Germany and the detailed steps were performed according to the reagent and instrument instructions 14 SNP loci associated with obesity and BMI were reliably validated based on GWAS studies in large Asian populations
The 4-week MVPA intervention engaged in supervised aerobic exercise resistance training and interesting sport for 60 minutes 3 daysweek Monday Wednesday and Friday No physical activity interventions were conducted in the control group In order to safeguard the rights of the control groups the same physical activity intervention was given to the control group at the end of the research
Physical activity strength was measured by Tri-axial body motion recorder ActiGraph Wgt3x-BT USA to maintain relative intensity At baseline Physical Activity Questionnaire for Children PAQ-C was answered by each participant
Height was measured to the nearest 01cm using Height Measuring Ruler Selcom Germany Body weight and fat mass was measured to the nearest 01kg using Body Composition Analyzer DC-13 Parade JapanWaist circumference and hip circumferencewas measured to the nearest 01cm with measuring tape
Preperitoneal fat and abdominal subcutaneous fat thickness were measured by ultrasonography The thickness and area of preperitoneal fat and abdominal subcutaneous fat were measured with a linear array probe L12-5 38 mm 5-12 HZ according to the method of Suzuki
The whole genomic DNA of blood mononuclear cells was performed using a fully automated nucleic acid extractor QIAGEN QIAcube Germany the DNA extraction reagents were used in a magnetic bead method DNA extraction kit QIAGEN 51331 Germany and the detailed steps were performed according to the reagent and instrument instructions 14 SNP loci associated with obesity and BMI were reliably validated based on GWAS studies in large Asian populations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None