Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06584552
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-21
Brief Title:
LaCE Lactobacillus Paracasei LPB27 On Early Childhood Eczema
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Lactobacillus Paracasei LPB27 On Early Childhood Eczema
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The LaCE study is a double-blind randomised placebo-controlled trial examining the effectiveness of the probiotic Lactobacillus paracasei LPB27 in treating eczema in young children
Detailed Description:
Childhood eczema is a common and chronic relapsing disease of the skin which affects up to 20 of the paediatric population Eczema has significant impact on the quality of life of those affected Its main symptoms are dry skin and intense itching
There is currently no cure for eczema but there are treatments that try to relieve symptoms These commonly include topical moisturisers and topical corticosteroids
Although topical corticosteroids are effective in minimising symptoms there is a prevailing and universal fear of using topical corticosteroids which is one of the main reasons for poor treatment compliance
There have been emerging interests in prevention and treatment of eczema through modulation of the gut microbiome The gut microbiome is a key regulator for the immune system and there is evidence that the composition of gut microbiome may reduce allergies by driving maturation of the immune system It was shown that people with eczema have different bacteria in their gut compared to people without eczema Therefore this studys hypothesis is that administration of oral probiotics will benefit young children with eczema by improving their gut microbiome and quality of life
There is currently no cure for eczema but there are treatments that try to relieve symptoms These commonly include topical moisturisers and topical corticosteroids
Although topical corticosteroids are effective in minimising symptoms there is a prevailing and universal fear of using topical corticosteroids which is one of the main reasons for poor treatment compliance
There have been emerging interests in prevention and treatment of eczema through modulation of the gut microbiome The gut microbiome is a key regulator for the immune system and there is evidence that the composition of gut microbiome may reduce allergies by driving maturation of the immune system It was shown that people with eczema have different bacteria in their gut compared to people without eczema Therefore this studys hypothesis is that administration of oral probiotics will benefit young children with eczema by improving their gut microbiome and quality of life
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None