Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06584786
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-04-02
Brief Title:
Therapeutic Effects of Jing Si Herbal Tea for COPD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Therapeutic Effects of Jing Si Herbal Tea for Chronic Obstructive Pulmonary Disease A Comprehensive Investigation From Clinical to Basic Research
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic obstructive pulmonary disease COPD a leading cause of global mortality significantly impairs health-related quality of life HRQL COPD is characterized by airway inflammation and lung tissue damage Jing Si herbal tea JSHT is known to have anti-inflammatory effects but has not been explored for treating COPD This study investigated the potential of JSHT as an adjuvant therapy for COPD This randomized controlled study focused on patients with COPD in the exacerbation and stable phases The control group received the standard treatment and the JSHT group received the standard treatment plus JSHT Both groups underwent HRQL assessments blood tests and cellular studies involving five different groups to assess the effect of JSHT on damage-associated molecular patterns DAMPs and inflammatory markers
Detailed Description:
Chronic obstructive pulmonary disease COPD is a common lung disease that impairs airflow and causes breathing difficulties COPD is a major contributor to chronic health issues and mortality globally it ranked as the third leading cause of death worldwide resulting in 323 million fatalities in 2019 Individuals with COPD typically develop lung damage or airway obstruction This condition is characterized by several common symptoms including coughing phlegm production difficulty breathing wheezing and fatigue The challenge in breathing frequently leads to reduced exercise endurance and diminished daily activity levels which negatively affects health-related quality of life HRQL Despite following the optimal treatment provided by the Global Initiative for chronic obstructive lung disease GOLD guidelines patients with COPD still experience significant disease effects This underscores the need for continued research on potential therapies for COPD
COPD is a gradually progressive airway disease Harmful agents such as cigarettes and infection are the primary risk factor for COPD The development of COPD involves airway inflammation and damage to the lung tissue Persistent exposure to harmful agents damages lung epithelial cells playing a crucial role in the pathogenesis of COPD During this process damage-associated molecular patterns DAMPs are released triggering inflammatory pathways and the release of pro-inflammatory cytokines such as interleukin IL-1 IL-6 IL-8 and tumor necrosis factor TNF-α These cytokines further activate inflammatory cells such as macrophages and neutrophils leading to further damage to lung tissues These inflammatory mechanisms offer insights into potentially effective treatments
Jing Si Herbal Tea JSHT is a herbal blend formulated to regulate the immune system and treat inflammatory respiratory conditions A recent study showed that combining JSHT with standard treatment in patients with COVID-19 improved clinical C-reactive protein levels and alleviated infections more effectively than standard treatment alone Additionally using JSHT decreases the risk of intubation critical conditions and mortality This suggests that JSHT may be a beneficial adjunct therapy for patients with COVID-19 However the therapeutic effects of JSHT in COPD have not yet been studied
Given that JSHT was designed for immune regulation and treatment of inflammatory diseases investigators hypothesized that JSHT could be beneficial for patients with COPD Therefore investigators study the therapeutic effects and precise mechanisms of action of JSHT in COPD This study provides a possible strategy for using JSHT as an adjuvant therapy for COPD
COPD is a gradually progressive airway disease Harmful agents such as cigarettes and infection are the primary risk factor for COPD The development of COPD involves airway inflammation and damage to the lung tissue Persistent exposure to harmful agents damages lung epithelial cells playing a crucial role in the pathogenesis of COPD During this process damage-associated molecular patterns DAMPs are released triggering inflammatory pathways and the release of pro-inflammatory cytokines such as interleukin IL-1 IL-6 IL-8 and tumor necrosis factor TNF-α These cytokines further activate inflammatory cells such as macrophages and neutrophils leading to further damage to lung tissues These inflammatory mechanisms offer insights into potentially effective treatments
Jing Si Herbal Tea JSHT is a herbal blend formulated to regulate the immune system and treat inflammatory respiratory conditions A recent study showed that combining JSHT with standard treatment in patients with COVID-19 improved clinical C-reactive protein levels and alleviated infections more effectively than standard treatment alone Additionally using JSHT decreases the risk of intubation critical conditions and mortality This suggests that JSHT may be a beneficial adjunct therapy for patients with COVID-19 However the therapeutic effects of JSHT in COPD have not yet been studied
Given that JSHT was designed for immune regulation and treatment of inflammatory diseases investigators hypothesized that JSHT could be beneficial for patients with COPD Therefore investigators study the therapeutic effects and precise mechanisms of action of JSHT in COPD This study provides a possible strategy for using JSHT as an adjuvant therapy for COPD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None