Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06589492
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-04
Brief Title:
Comparison of Serum SIRT-1 and MMP-9 Levels of Patients With Bronchiectasis and Healthy Controls
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Cross-sectional Study on the Comparison of Serum SIRT-1 and MMP-9 Levels of Patients With Bronchiectasis and Healthy Controls
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this a cross-sectinol study is to measure the levels of MMP-9 and SIRT-1 levels in patients with bronchiectasis and healthy controls The aim is to compare the serum levels of these molecules between patients and controls
Is the MMP-9 level increasing or decreasing
Is the SIRT-1 level increasing or decreasing in patients
Is the disease related to age and gender Participants will only have one 5 ml blood sample drawn when they visit the chest illness clinic Molecule levels will be measured in this bloods serum
The patient group participants will be scanned once with high-resolution chest CT
Apart from this comparisons will be made using the age and gender information of the participants
Is the MMP-9 level increasing or decreasing
Is the SIRT-1 level increasing or decreasing in patients
Is the disease related to age and gender Participants will only have one 5 ml blood sample drawn when they visit the chest illness clinic Molecule levels will be measured in this bloods serum
The patient group participants will be scanned once with high-resolution chest CT
Apart from this comparisons will be made using the age and gender information of the participants
Detailed Description:
In the overall study population of 60 subjects who applied to the Sivas Cumhuriyet University Faculty of Medicine Research and Practice Hospital Chest Diseases Clinic The study population was selected regardless of age and gender Participants selected bronchiectasis patients n30 who had symptoms cough sputum production and had their diagnosis confirmed by a chest high-resolution CT scan within the previous year The study excluded individuals with bronchiectasis not associated with cystic fibrosis and who had a worsening episode according to the 2017 European Respiratory Society expert consensus criteria 16 or had taken antibiotics during the previous four weeks The study enrolled healthy controls n30 through advertisements who had acceptable chest X-ray and spirometry results and no lower airway symptoms or serious systemic disorders The study eliminated individuals who were pregnant or nursing as well as those with low comprehension SIRT-1 and MMP-9 levels in the serum of the study group were determined by the ELISA method
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None