Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06589999
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-02
Brief Title:
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SCOUT-MS
Brief Summary:
Since the last revision of the MRI guidelines in multiple sclerosis MS MAGNIMS and the McDonald criteria in 2017 all spinal cord lesions must be counted to increase the sensitivity and specificity of the diagnosis of MS Focal lesions of the spinal cord are more frequently located in the cervical segments than in the lower segments of the spinal cord and occupy the lateral and posterior columns although the central grey matter may not be spared Cervical involvement is difficult to study because of the small size of the lesions and the loss of signal in the cervical region As a result the detection of cervical lesions on MRI is sub-optimal
In this context standardised acquisition protocols have been proposed
For MRI of the spinal cord at least two of the following sagittal sequences are recommended T2 STIR double inversion recovery T1 with gadolinium injection andor T2 axial acquisitions
Recently our team validated the superiority of 3D PSIR and 3D FGAPSIR sequences which offer better detection performance than T2 and STIR on 3 Tesla MRI
Other studies have also shown the contribution of the MP2RAGE sequence to the detection of spinal cord lesions in MS compared with the set of sequences classically recommended The MP2RAGE sequence is a T1 sequence which creates a composite image limiting field inhomogeneity bias while providing a quantitative T1 map It has recently been optimised for the spinal cord and has been only minimally evaluated in the context of MS
The aim of this study is to evaluate the effectiveness of the MP2RAGE sequence in comparison with the set of conventional sequences recommended for the detection of spinal cord lesions in MS patients
In this context standardised acquisition protocols have been proposed
For MRI of the spinal cord at least two of the following sagittal sequences are recommended T2 STIR double inversion recovery T1 with gadolinium injection andor T2 axial acquisitions
Recently our team validated the superiority of 3D PSIR and 3D FGAPSIR sequences which offer better detection performance than T2 and STIR on 3 Tesla MRI
Other studies have also shown the contribution of the MP2RAGE sequence to the detection of spinal cord lesions in MS compared with the set of sequences classically recommended The MP2RAGE sequence is a T1 sequence which creates a composite image limiting field inhomogeneity bias while providing a quantitative T1 map It has recently been optimised for the spinal cord and has been only minimally evaluated in the context of MS
The aim of this study is to evaluate the effectiveness of the MP2RAGE sequence in comparison with the set of conventional sequences recommended for the detection of spinal cord lesions in MS patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None