Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06593041
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-04
Brief Title:
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
Sponsor:
None
Organization:
None
Study Overview
Official Title:
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PLAQUETTOLUP
Brief Summary:
Blood platelets well known for their role in hemostasis are abnormally activated in patients suffering from systemic lupus erythematosus SLE but also from other immunomediated diseases scleroderma vasculitis myositis Gougerot-Sjögrens and rheumatoid arthritis in cases of high disease activity Once activated platelets express adhesion molecules such as P-selectin on their surface enabling them to interact physically with immune cells In a recent work we identified that activated platelets from lupus patients interact with regulatory T cells and block their regulatory function thus participating in the deregulated activation of the immune system in SLE In addition inhibition of platelet-immune cell interactions by an anti-P-selectin antibody improved LES symptoms in two mouse models
The aim of this work is to investigate other potential platelet-immune cell interactions in patients with SLE in comparison with other autoimmune diseases systemic scleroderma ANCA vasculitides inflammatory myositis Gougerot-Sjögren syndrome and rheumatoid arthritis
This study could lead to a better understanding of the role of platelets in the pathophysiology of autoimmune diseases identify new biomarkers of activity and assess the potential of new therapeutic avenues in these diseases such as platelet targeting
The aim of this work is to investigate other potential platelet-immune cell interactions in patients with SLE in comparison with other autoimmune diseases systemic scleroderma ANCA vasculitides inflammatory myositis Gougerot-Sjögren syndrome and rheumatoid arthritis
This study could lead to a better understanding of the role of platelets in the pathophysiology of autoimmune diseases identify new biomarkers of activity and assess the potential of new therapeutic avenues in these diseases such as platelet targeting
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None