Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06593366
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-26
Brief Title:
Fecal Microbiota Transplant for Anorexia Nervosa
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Pilot Feasibility Randomized Controlled Trial of Fecal Microbiota Transplant for Adolescent Anorexia Nervosa
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FMT-AN
Brief Summary:
The purpose of this pilot randomized-controlled trial is to determine whether Fecal Microbiota Transplant FMT treatment demonstrates feasibility acceptability and prelinary effectiveness among patients with anorexia nervosa AN Specifically the investigators aim to compare changes in weight gut microbiome urine blood biomarkers and mood symptoms between participants receiving the FMT intervention and placebo
Detailed Description:
In the following pilot randomized-controlled trial the investigators aim is to determine whether FMT treatment demonstrates feasibility acceptability and preliminary effectiveness in pediatric AN participants The investigators will assess how the use of FMT affects participants rate of weight restoration gut microbiome relevant urine and blood biomarkers and mood symptoms The investigators rationale for performing the study is to better understand the interactions between the intestinal microbiome energy regulation and behavior This will be the first study to assess the role of FMT in pediatric AN and will help establish whether this adjunctive treatment modality has benefit in managing the metabolic and behavioral manifestations of this complex neuropsychiatric disorder
In terms of study procedures members of a pilot sample of 20 AN patients recruited from McMaster Childrens Hospital will be randomized to receive FMT or placebo All participants will be asked to complete a battery of assessments at regular intervals over the 8-week intervention period and at a follow-up point at four weeks post-intervention
The studys primary outcomes are recruitment and retention rates Descriptive statistics will be used to determine the number of adolescents who will agree to participate in the study and those who will complete the study
One of the studys secondary outcomes is participants attitudes toward FMT This will be measured through qualitative interviews among those who completed the intervention and those who do not agree to participate in the study
The investigators will know we have reached saturation by using a method called information power and will explore how broad the research questions are if there are clear theories to guide the analysis how varied the participants in the study are and how much useful information is accrued Based on this the investigators will determine the appropriate number of interviews to lead
The remaining secondary outcome is a battery of preliminary outcomes clinical biological biochemical and safety The investigators will assess these outcomes at multiple timepoints using questionnaires anthropometric data stool analysis 16s rRNA urine metabolic analysis saliva ultra filtrates changes in blood work and common terminology criteria for adverse events for safety outcomes
In terms of study procedures members of a pilot sample of 20 AN patients recruited from McMaster Childrens Hospital will be randomized to receive FMT or placebo All participants will be asked to complete a battery of assessments at regular intervals over the 8-week intervention period and at a follow-up point at four weeks post-intervention
The studys primary outcomes are recruitment and retention rates Descriptive statistics will be used to determine the number of adolescents who will agree to participate in the study and those who will complete the study
One of the studys secondary outcomes is participants attitudes toward FMT This will be measured through qualitative interviews among those who completed the intervention and those who do not agree to participate in the study
The investigators will know we have reached saturation by using a method called information power and will explore how broad the research questions are if there are clear theories to guide the analysis how varied the participants in the study are and how much useful information is accrued Based on this the investigators will determine the appropriate number of interviews to lead
The remaining secondary outcome is a battery of preliminary outcomes clinical biological biochemical and safety The investigators will assess these outcomes at multiple timepoints using questionnaires anthropometric data stool analysis 16s rRNA urine metabolic analysis saliva ultra filtrates changes in blood work and common terminology criteria for adverse events for safety outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None