Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06594250
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-10
Brief Title:
Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S Aureus Bacteremia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S Aureus Bacteremia
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RISTA
Brief Summary:
Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate with or without associated infective endocarditis IE long hospital stays and multiple complications due to the terrain in which it occurs and its secondary localization They may be community-acquired or healthcare-associated infections Being a carrier of S aureus is a known risk factor for S aureus bacteremia Although several mucosal sites of carriage have been described screening for carriage is most often carried out at the nasal level both for reasons of simplicity and because it is the predominant site of carriage of this bacterium However S aureus carriage is a frequent occurrence affecting around 13 of the general population
Detailed Description:
Long considered an extracellular bacterium the investigators now know that S aureus can have an intracellular reservoir This was initially described in situations of infection bone infections vascular infections and more recently in situations of nasal carriage without associated infection Among S aureus carriers between 15 and 30 have an intracellular reservoir of this bacterium depending on the study in patients with no S aureus infection For S aureus carriers with S aureus infection there are no data in the literature The clinical significance of this intracellular reservoir in a carrier situation is currently unknown The study team was able to demonstrate in vitro that this reservoir was not affected by the mupirocin used in decolonization and preliminary results suggest that in vivo this reservoir may also be associated with decolonization failure
Moreover in vitro it has been suggested that S aureus may act on autophagy to promote intracellular survival Is the intracellular reservoir more frequent in patients with S aureus bacteremia Is it associated with a poorer prognosis in S aureus bacteremia Is it associated with the production of certain S aureus intracellular persistence factors Is it associated with a slowdown in autophagic flow in nasal cells or phagocytes These questions remain unanswered to this day
To explore these questions the investigators plan to conduct a study to assess the frequency of the intracellular S aureus reservoir within carriers in S aureus bacteremia and in bacteremia to another pathogen control group They would also like to study the impact of this reservoir on the persistence of carriage and prognosis death duration of bacteremia length of stay presence of secondary localizations of bacteremia or endocarditis in the case of S aureus bacteremia
Moreover in vitro it has been suggested that S aureus may act on autophagy to promote intracellular survival Is the intracellular reservoir more frequent in patients with S aureus bacteremia Is it associated with a poorer prognosis in S aureus bacteremia Is it associated with the production of certain S aureus intracellular persistence factors Is it associated with a slowdown in autophagic flow in nasal cells or phagocytes These questions remain unanswered to this day
To explore these questions the investigators plan to conduct a study to assess the frequency of the intracellular S aureus reservoir within carriers in S aureus bacteremia and in bacteremia to another pathogen control group They would also like to study the impact of this reservoir on the persistence of carriage and prognosis death duration of bacteremia length of stay presence of secondary localizations of bacteremia or endocarditis in the case of S aureus bacteremia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None