Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06594315
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-09-04
Brief Title:
Assessing Brain Metabolism Using MRS With Deuterated Glucose
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessing Brain Metabolism Using 1H MRS With Deuterated Glucose
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate the use of Hydrogen 1 1H magnetic resonance spectroscopy MRS with deuterated glucose 2H-glucose to detect dynamic glucose uptake in the brain
Detailed Description:
PRIMARY OBJECTIVE
1 To define the most appropriate imaging parameters of 1H MRS for obtaining deuterium-labeled glucose metabolism Cohorts 1 and 2
2 To evaluate treatment induced metabolic changes after the administration of 2H-glucose in participants with glioma Cohort 3
OUTLINE
Participants with and without glioma will be evaluated to develop a robust strategy for obtaining 2H-glucose metabolism in twenty healthy participants cohort 1 and thirty participants with glioma cohort 2 while the remaining thirty glioma participants will be studied at baseline and after completion of non-investigational therapy cohort 3
1 To define the most appropriate imaging parameters of 1H MRS for obtaining deuterium-labeled glucose metabolism Cohorts 1 and 2
2 To evaluate treatment induced metabolic changes after the administration of 2H-glucose in participants with glioma Cohort 3
OUTLINE
Participants with and without glioma will be evaluated to develop a robust strategy for obtaining 2H-glucose metabolism in twenty healthy participants cohort 1 and thirty participants with glioma cohort 2 while the remaining thirty glioma participants will be studied at baseline and after completion of non-investigational therapy cohort 3
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None