Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06594900
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-09-10
Brief Title:
Development of Muscle Function in Prepubertal Children As a Response to Growth and Resistance Training
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Muscle Growth and Development of Neuromuscular Capacities in Prepubertal Children - a Randomized Controlled Intervention Study
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
decade-fit
Brief Summary:
Healthy skeletal muscle development is crucial for a life-long quality of life Childhood and puberty may be key periods for developing muscle growth and neuromuscular capacities which are essential for bone-muscle interaction metabolism and participation in various sports Even though the central role of physical activity in healthy physical development is well recognized the decline in muscular fitness in todays children is alarming This can lead to lasting deficits in muscle development and have a negative impact on overall health
Well-designed resistance training RT could address this problem since it has an effective positive impact on muscular strength bone density metabolism and spontaneous physical activity especially in childhood In general muscles adapt according to physical activity stimuli However children show different responses to exercise and training The physiologic differences which are reflected in lower neuromuscular capacities and hormonal responses but also in a better resistance to fatigue than in adults are not yet fully understood It is well established that RT in children is safe effective and has multiple benefits for health However the underlying mechanisms that lead to increased muscle strength are unclear and it is unknown how sustainable these are
Todays common conception is that increased muscular strength is predominantly caused by neural adaptations and changes in muscle morphology due to lower androgenic responses are negligible
Although higher neuromuscular adaptation potential is evident it is still not sufficient to explain all strength increases suggesting that additional mechanisms are involved in the process Most studies are outdated had methodological and statistical limitations and many state-of-the-art methods have not yet been applied to children hence there is a need for a comprehensive in-depth investigation to understand muscle adaptations to training and growth in children With this better understanding of the impact and adaption to RT stimuli on neuromuscular and structural development the proposed project can serve as a foundation for more targeted prevention strategies
The aim of this study is to investigate neuromuscular hormonal and morphological adaptations following 4 and 20 weeks of RT while also examining their longitudinal retention through two consecutive follow-ups over 15 years In this randomized controlled trial state-of-the-art measurement methods are employed to accurately delve into mechanisms of adaptation some of which have not yet used in children before due to limited time or infrastructure resources The neuromuscular assessments include maximal and explosive strength of leg extensors voluntary activation motor unit decomposition as well as central and peripheral neuromuscular fatigability The hormonal changes are measured acutely testosterone cortisol IGF-1 and growth hormone and chronically testosterone progesterone and IGF-1 in response to one or several training sessions Static and dynamic ultrasound imagining is used to quantify muscle size fascicle shortening velocity and muscle architecture This design allows in-depth insights into short- and long-term adaptations on several physiological levels to provide a novel mechanistic understanding of muscle growth and function in children
The major innovation of this research is the integration of diverse scientific perspectives combining insights from neuromuscular physiology endocrinology and muscle morphology to provide a holistic understanding of RT adaptations and development in children of both sexes
This comprehensive approach can form the basis for future training programs enabling next generations to better understand the potential impact of musculature on health
Well-designed resistance training RT could address this problem since it has an effective positive impact on muscular strength bone density metabolism and spontaneous physical activity especially in childhood In general muscles adapt according to physical activity stimuli However children show different responses to exercise and training The physiologic differences which are reflected in lower neuromuscular capacities and hormonal responses but also in a better resistance to fatigue than in adults are not yet fully understood It is well established that RT in children is safe effective and has multiple benefits for health However the underlying mechanisms that lead to increased muscle strength are unclear and it is unknown how sustainable these are
Todays common conception is that increased muscular strength is predominantly caused by neural adaptations and changes in muscle morphology due to lower androgenic responses are negligible
Although higher neuromuscular adaptation potential is evident it is still not sufficient to explain all strength increases suggesting that additional mechanisms are involved in the process Most studies are outdated had methodological and statistical limitations and many state-of-the-art methods have not yet been applied to children hence there is a need for a comprehensive in-depth investigation to understand muscle adaptations to training and growth in children With this better understanding of the impact and adaption to RT stimuli on neuromuscular and structural development the proposed project can serve as a foundation for more targeted prevention strategies
The aim of this study is to investigate neuromuscular hormonal and morphological adaptations following 4 and 20 weeks of RT while also examining their longitudinal retention through two consecutive follow-ups over 15 years In this randomized controlled trial state-of-the-art measurement methods are employed to accurately delve into mechanisms of adaptation some of which have not yet used in children before due to limited time or infrastructure resources The neuromuscular assessments include maximal and explosive strength of leg extensors voluntary activation motor unit decomposition as well as central and peripheral neuromuscular fatigability The hormonal changes are measured acutely testosterone cortisol IGF-1 and growth hormone and chronically testosterone progesterone and IGF-1 in response to one or several training sessions Static and dynamic ultrasound imagining is used to quantify muscle size fascicle shortening velocity and muscle architecture This design allows in-depth insights into short- and long-term adaptations on several physiological levels to provide a novel mechanistic understanding of muscle growth and function in children
The major innovation of this research is the integration of diverse scientific perspectives combining insights from neuromuscular physiology endocrinology and muscle morphology to provide a holistic understanding of RT adaptations and development in children of both sexes
This comprehensive approach can form the basis for future training programs enabling next generations to better understand the potential impact of musculature on health
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None