Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06598033
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-11
Brief Title:
Vitamin C Plus Herbal Medicine to Quality of Life in Patients with Terminal Stage Pancreatic Cancer
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Vitamin C Plus Herbal Medicine to Quality of Life in Patients with Terminal Stage Pancreatic Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to evaluate the efficacy of vitamin C plus herbal medicine in improving the quality of life for metastatic pancreatic cancer patients who are resistant to chemotherapy
Detailed Description:
Pancreatic cancer is a highly lethal malignancy with a 5-year survival less than 10 Approximately 80 of patients with pancreatic cancer are diagnosed at an advanced stage Chemotherapy is one of the major treatments for advanced pancreatic cancer In 2011 the PRODIGE trial has shown that oxaliplatin irinotecan fluorouracil and leucovorin FOLFIRINOX was associated with a survival advantage but had increased toxicity In 2013 the MPACT trial has confirmed the efficacy of gemcitabine combined with nab-paclitaxel as the first-line treatment to metastatic pancreatic cancer However the side-effects related to chemotherapy including anemia handfoot numbness fatigue nausea and malnutrition have impaired the quality of life for patients
Vitamin C also called ascorbate is an essential nutrient for the human body It modulates metabolism immune reaction collagen synthesis and iron absorption Some studies have shown that high-dose intravenous Vitamin C may be effective against various types of cancer Meanwhile medium or low dose of Vitamin C may increase iron absorption improve anemia alleviate pain and handfoot numbness and thus improve the quality of life for patients with terminal stage pancreatic cancer In addition numerous evidence has proved the efficacy of Reishi and Cordyceps in alleviating the side effects related to chemotherapy
The purpose of this study is to evaluate the efficacy of vitamin C plus herbal medicine on improving the quality of life for metastatic pancreatic cancer patients who are resistant to two lines of systemic chemotherapy including gemcitabine based fluorouracil based or other regimen Fifty patients who have tumor progression after receiving two lines of chemotherapy will be recruited These patients will receive Vitamin C plus herbal medicine Quality of life rate of handfoot numbness severity of pain rate of anemia and overall survival are measured
Vitamin C also called ascorbate is an essential nutrient for the human body It modulates metabolism immune reaction collagen synthesis and iron absorption Some studies have shown that high-dose intravenous Vitamin C may be effective against various types of cancer Meanwhile medium or low dose of Vitamin C may increase iron absorption improve anemia alleviate pain and handfoot numbness and thus improve the quality of life for patients with terminal stage pancreatic cancer In addition numerous evidence has proved the efficacy of Reishi and Cordyceps in alleviating the side effects related to chemotherapy
The purpose of this study is to evaluate the efficacy of vitamin C plus herbal medicine on improving the quality of life for metastatic pancreatic cancer patients who are resistant to two lines of systemic chemotherapy including gemcitabine based fluorouracil based or other regimen Fifty patients who have tumor progression after receiving two lines of chemotherapy will be recruited These patients will receive Vitamin C plus herbal medicine Quality of life rate of handfoot numbness severity of pain rate of anemia and overall survival are measured
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None