Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06599125
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-10
Brief Title:
Risk Factors of Mortality in Neonatal Pneumonia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Risk Factors of Mortality in Neonatal Pneumonia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Neonatal pneumonia a lower chest infectious disease is one of the most serious and fatal diseases in young infants1 Neonates may catch pneumonia vertically from mother or horizontally from the environment at birth time
Detailed Description:
Neonatal pneumonia a lower chest infectious disease is one of the most serious and fatal diseases in young infants Neonates may catch pneumonia vertically from mother or horizontally from the environment at birth time Time of catching infection can be classified into
Prenatal thats intrauterine it is also called Congenital Pneumonia The pathogen may investigate the neonatal lung intrauterine through chrioamniotic membranes or trans-placental
At birth during the first week after birth Early onset pneumonia however pathogen mat be from intrauterine or at birth canal and mostly this type of pneumonia is bacterial
After the first week of life late onset pneumonia It is common to be of nosocomial or community acquired
Neonatal Pneumonia is the second leading cause of death after neonatal sepsis It accounts for 152000 to 490000 of infants aged lt 1 year annually Research papers reported that in 2016 26 million neonatal deaths were reported representing a global burden of 19 neonatal deaths per 1000 live births and in 2017 the annual neonatal mortality rate NMR was highest in east west and central Africa About specific-cause-mortality of these estimations lower chest infection represented 135 of these deaths and had the highest incidece in the first 28 days of life in live birth
In the majority of cases causing pathogen of neonatal pneumonia is viral however community and hospital acquired pneumonia are frequently bacterial that caused by Haemophilus influenzae Streptococcus agalactiae or Enterobacteriaceae species Although pneumonia occurs in all ages neonatal pneumonia is associated with comorbidities and mortality in age below 59 days
Lung of newborn is volurnable to pneumonia due to variable risk factors Some of these factors are attributed to mother other to neonate and the rest is to labor circumstances In general neonate is suseptabile to infection due to weak immunity a factor that is more potentiating in premature neonate However maternal risk factors resulting in congenital pneumonia are for example represented in systemic diseases infection during pregnancy as toxoplasmosis cytomegalovirus CMV herpes simplex virus HSV Neonates catch early onset pneumonia in perinatal duration whether before labor through placenta ascending infection intrauterine or from pathogens in birth canal during vaginal delivery Late onset pneumonia is due to exposure to the pathogen in community although a common risk factor for late onset pneumonia is low birth weight and prematurityReported factors that potentiate mortality in case pneumonia are living in developing countries drining infested water maternal smoking late starting of treatment and the more younger of child the higher risk they are in
Diagnosis of neonatal pneumonia is difficult in neonates because they may experience no symptoms or have symptoms that are part of other syndromes unlike older children or adults that have clear symptoms In this study we aim to evaluate the clinical laboratory radiological and other risk factors that predict mortality in term and preterm 32 to 36 weeks neonates admitted with pneumonia in neonatalogy unit in Assuit university Children hospital
Prenatal thats intrauterine it is also called Congenital Pneumonia The pathogen may investigate the neonatal lung intrauterine through chrioamniotic membranes or trans-placental
At birth during the first week after birth Early onset pneumonia however pathogen mat be from intrauterine or at birth canal and mostly this type of pneumonia is bacterial
After the first week of life late onset pneumonia It is common to be of nosocomial or community acquired
Neonatal Pneumonia is the second leading cause of death after neonatal sepsis It accounts for 152000 to 490000 of infants aged lt 1 year annually Research papers reported that in 2016 26 million neonatal deaths were reported representing a global burden of 19 neonatal deaths per 1000 live births and in 2017 the annual neonatal mortality rate NMR was highest in east west and central Africa About specific-cause-mortality of these estimations lower chest infection represented 135 of these deaths and had the highest incidece in the first 28 days of life in live birth
In the majority of cases causing pathogen of neonatal pneumonia is viral however community and hospital acquired pneumonia are frequently bacterial that caused by Haemophilus influenzae Streptococcus agalactiae or Enterobacteriaceae species Although pneumonia occurs in all ages neonatal pneumonia is associated with comorbidities and mortality in age below 59 days
Lung of newborn is volurnable to pneumonia due to variable risk factors Some of these factors are attributed to mother other to neonate and the rest is to labor circumstances In general neonate is suseptabile to infection due to weak immunity a factor that is more potentiating in premature neonate However maternal risk factors resulting in congenital pneumonia are for example represented in systemic diseases infection during pregnancy as toxoplasmosis cytomegalovirus CMV herpes simplex virus HSV Neonates catch early onset pneumonia in perinatal duration whether before labor through placenta ascending infection intrauterine or from pathogens in birth canal during vaginal delivery Late onset pneumonia is due to exposure to the pathogen in community although a common risk factor for late onset pneumonia is low birth weight and prematurityReported factors that potentiate mortality in case pneumonia are living in developing countries drining infested water maternal smoking late starting of treatment and the more younger of child the higher risk they are in
Diagnosis of neonatal pneumonia is difficult in neonates because they may experience no symptoms or have symptoms that are part of other syndromes unlike older children or adults that have clear symptoms In this study we aim to evaluate the clinical laboratory radiological and other risk factors that predict mortality in term and preterm 32 to 36 weeks neonates admitted with pneumonia in neonatalogy unit in Assuit university Children hospital
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None