Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06603207
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-17
Brief Title:
Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Causal Association Between Rheumatoid Arthritis and Periodontitis A Mendelian Randomization Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RAPD-MR
Brief Summary:
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization Data will be sourced from genome-wide association studies GWAS to explore genetic associations and assess potential risk factors in an East Asian population
Detailed Description:
The purpose of this study is to explore the causal association between rheumatoid arthritis RA and periodontitis using Mendelian randomization MR RA and periodontitis share similar inflammatory pathways and immune responses but their causal relationship remains unclear This study will utilize genome-wide association studies GWAS data from an East Asian population to identify single nucleotide polymorphisms SNPs associated with RA and assess their potential impact on the risk of developing periodontitis Statistical methods such as inverse-variance weighting MR-Egger regression and weighted median analysis will be employed to analyze the data The findings may provide insights into the shared genetic basis and causal relationships between these two conditions offering potential targets for preventive strategies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None