Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06606236
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-14
Brief Title:
Neuropeptide Y Regulates Neurogenic Pulp Inflammation
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Neuropeptide Y Regulates Tooth Bleaching Agent-induced Neurogenic Pulp Inflammation An In-Vivo Study
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objective This study assessed the neuropeptide Y NPY expression in healthy human dental pulp following tooth bleaching with three in-office hydrogen peroxide-based systems Opalescence Boost Ultradent Products South Jordan UT Pola Office SDI Victoria Australia and Zoom Zoom Bleaching System Discuss Dental Culver City CA
Materials and Methods Forty dental pulps were collected from healthy premolars scheduled for extraction for orthodontic reasons Teeth were divided into four groups containing ten healthy premolars each Control group n 10 the teeth were not exposed to dental bleaching agents healthy pulps assessed for normalbasal NPY values Pola Office system group n 10 application of Pola office 35 H2O2 for 8 minutes Opalescent Boost system group n 10 application of Opalescent Boost 40 H2O2 for 20 minutes Zoom system group n 10 application of Zoom 25 H2O2 cold blue light for 15 minutes The investigators rigorously followed the manufacturers instructions for all bleaching systems Following the extractions the pulpal tissue was collected placed in a 4 formaldehyde solution in Eppendorf tubes and processed NPY levels were measured using enzyme-linked immunosorbent assay ELISA
Materials and Methods Forty dental pulps were collected from healthy premolars scheduled for extraction for orthodontic reasons Teeth were divided into four groups containing ten healthy premolars each Control group n 10 the teeth were not exposed to dental bleaching agents healthy pulps assessed for normalbasal NPY values Pola Office system group n 10 application of Pola office 35 H2O2 for 8 minutes Opalescent Boost system group n 10 application of Opalescent Boost 40 H2O2 for 20 minutes Zoom system group n 10 application of Zoom 25 H2O2 cold blue light for 15 minutes The investigators rigorously followed the manufacturers instructions for all bleaching systems Following the extractions the pulpal tissue was collected placed in a 4 formaldehyde solution in Eppendorf tubes and processed NPY levels were measured using enzyme-linked immunosorbent assay ELISA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None