Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06607068
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-09-18
Brief Title:
Assessment of Taurine Concentration in Older Women WithWithout Obesity And WithWithout Type 2 Diabetes Mellitus
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment of Taurine Concentration in Older Women WithWithout Obesity And WithWithout Type 2 Diabetes Mellitus a Cross-Sectional Study
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aging is a multifactorial process marked by several epigenetic and molecular changes such as telomere shortening DNA exposure to damage mitochondrial dysfunction accumulation of senescent cells and oxidative stress Such changes lead to the degeneration of cells and molecules which affects tissues organs and systems over time reducing the human body39s ability to resist damage and favoring the development of chronic diseases such as Type 2 Diabetes Mellitus T2DM Taurine a semi-essential amino acid appears to be related to oxidative homeostasis glucose control and inflammation Therefore knowing the plasma concentrations of this amino acid in different populations is necessary to obtain a better understanding of the role of taurine in the pathophysiology of obesity and T2DM in older population in addition to generating hypotheses regarding interventions capable of attenuating oxidative stress and inflammation which are important hallmarks of aging
Detailed Description:
The aim of this study is to investigate whether health status women with obesity T2DM and no comorbidities promotes changes in plasma taurine concentration and to correlate this concentration with biochemical markers eg blood glucose total cholesterol insulin glycated hemoglobin triglycerides and HDL cholesterol As well as to evaluate and compare the physical capacities of the different groups Methods Forty older women will participate in the cross-sectional study and will be allocated into four distinct groups and will be classified as follows older women with obesity and T2DM older women with obesity and no T2DM older women without obesity and with T2DM eutrophic older women with 10 older women in each group The following will be performed body composition assessment by total and regional body scanning using iDXA anthropometry tests to assess physical performance peripheral blood collection for analysis of biochemical markers and the Physical Activity Level will be assessed using the Modified Baecke Questionnaire for Olders For statistical analysis One-way ANOVA will be used to verify the differences and compare the four groups Expected results It is expected that older women with obesity and T2DM will have lower plasma taurine concentration and also lower performance in physical tests compared to the other groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None