Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06610942
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-20
Brief Title:
Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PSOFUNGI
Brief Summary:
Psoriasis is a chronic immune-mediated skin disorder characterized by inflammatory cutaneous plaques and occasionally arthritis affecting 60 million adults and children worldwide Although a variety of treatments have been developed aimed to relieve the associated symptoms there is yet no permanent cure for psoriasis TH17 type immunity via the production of IL-17A and other pro-inflammatory cytokines are considered to play a central role in the pathogenesis of this disease Moreover experimental evidence obtained in animal models points to human mycobiota as a trigger for the initiation andor progression of psoriasis Therefore human studies are required to better characterize the major fungi implicated in the local and systemic inflammatory responses as well as to determine the immunopeptidome that shapes the pathogenic T cell receptor repertoire
We will explore the hypothesis that commensal fungi could participate in the chronic inflammatory immune response underlying the pathogenesis of human psoriasis via the recognition of cutaneous fungal antigens andor via a gut-skin mycobiome cross-reactive mechanism
We will explore the hypothesis that commensal fungi could participate in the chronic inflammatory immune response underlying the pathogenesis of human psoriasis via the recognition of cutaneous fungal antigens andor via a gut-skin mycobiome cross-reactive mechanism
Detailed Description:
The overall aim of the project is
i to characterize the nature of human local and systemic inflammatory responses against commensal skin and gut fungal species in psoriatic patients PsoP and ii to determine the fungal immunopeptidome that contributes to the shaping of the T cell receptor TCR repertoire of skin-infiltrating T cells The project is divided into four major scientific objectives
1 To determine the mycobiome profiles in healthy donors HD and PsoP
2 To characterize the contribution of mycobiota to the local cutaneous CD4 T cell response
3 To assess systemic the CD4 T cell-fungal cross-reactivity
4 To establish the immunopeptidome of the major CD4 T cell-reactive fungus enabling the development of an innovative immunotherapy
i to characterize the nature of human local and systemic inflammatory responses against commensal skin and gut fungal species in psoriatic patients PsoP and ii to determine the fungal immunopeptidome that contributes to the shaping of the T cell receptor TCR repertoire of skin-infiltrating T cells The project is divided into four major scientific objectives
1 To determine the mycobiome profiles in healthy donors HD and PsoP
2 To characterize the contribution of mycobiota to the local cutaneous CD4 T cell response
3 To assess systemic the CD4 T cell-fungal cross-reactivity
4 To establish the immunopeptidome of the major CD4 T cell-reactive fungus enabling the development of an innovative immunotherapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None