Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06611618
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-17
Brief Title:
Analysis of the Loss of Muscle Force Muscle Power and Motor Control Degradation to Predict the Risk of Falls in Patients With Knee Osteoarthritis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Analisi Della Perdita di Forza e Potenza Muscolare e Del Degrado Del Controllo Motorio Per la Predizione Delle Cadute in Una Popolazione Affetta da Artrosi di Ginocchio
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PowerAGING
Brief Summary:
The twofold goal of this study is to understand the link between muscle power muscle strength and muscle control degradation with the risk of falling and to develop a framework for the comprehensive and quantitative assessment of muscle power and strength in an elderly population of patients with knee osteoarthritis who are at higher risk of falling The main question it aims to answer is
Are muscle power and motor control degradation better predictors of falls than muscle strength in the aging population
Participants will undergo
Muscle force assessment on a dynamometer
Muscle power assessment on a dynamometer and on isntrumented stairs
Home-based mobility monitoring
Full lower limb MRI acquisition
Gait assessment
Are muscle power and motor control degradation better predictors of falls than muscle strength in the aging population
Participants will undergo
Muscle force assessment on a dynamometer
Muscle power assessment on a dynamometer and on isntrumented stairs
Home-based mobility monitoring
Full lower limb MRI acquisition
Gait assessment
Detailed Description:
Falls are a critical yet common event among the elderly with huge societal and economic impact reduced quality of life and high costs for the healthcare system Experimental measures to quantify the residual muscle strength and power may provide useful information to predict the risk of falls in the elderly Isometric and isokinetic muscle contractions performed on a dynamometer or during functional tasks can be collected together with electromyography to assess muscle activity and imaging data to quantify and characterize muscular tissue
Such data can be collected at different time points to monitor subjects over time and to inform virtual representation of the human musculoskeletal system digital twins to identify possible motor control deficits Moreover this same information can be used to better characterizeassess elder individuals at risk of falling eg subjects with knee osteoarthritis to prevent future falls
All subjects enrolled in the PowerAGING study will be followed up for 24 months 5 visits in total M0 M6 M12 M18 and M24 follow-up At each visit a series of experimental tests to quantify muscle power and muscle force as well as a home-based mobility assessment via single inertial sensor worn for 5 consecutive days will be performed In addition only at start and end the subjects will undergo a full lower limb MRI and a gait assessment
Such data can be collected at different time points to monitor subjects over time and to inform virtual representation of the human musculoskeletal system digital twins to identify possible motor control deficits Moreover this same information can be used to better characterizeassess elder individuals at risk of falling eg subjects with knee osteoarthritis to prevent future falls
All subjects enrolled in the PowerAGING study will be followed up for 24 months 5 visits in total M0 M6 M12 M18 and M24 follow-up At each visit a series of experimental tests to quantify muscle power and muscle force as well as a home-based mobility assessment via single inertial sensor worn for 5 consecutive days will be performed In addition only at start and end the subjects will undergo a full lower limb MRI and a gait assessment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None