Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06615440
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-16
Brief Title:
Management and Outcome of Scorpion Sting in Children
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Management and Outcome of Scorpion Sting in Children
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the clinical characteristics of children with scorpion sting and implement guidelines for management of those children and observe the outcome
Detailed Description:
Scorpion envenomation is a severesometimes fatal medical condition especially in children Worldwidethere are more than 12 million scorpion stings each yearmostly in tropical and subtropical regionsEvery yearmore than 420000 snake bitescorpion sting and spider bite incidents occur in the Middle East and North Africa MENAIn the region of Assiutin the South of Egyptthe annual incidence and mortality by scorpion stings has been reported to be 88 and 55 per 100000 inhabitantsThere are 1500 sub species of scorpions in the globeand 50 of those have venom that is harmful to humansThe most toxic scorpion families are the Buthidae familyThe MENA region is home to 27 species of scorpions from three familiestheButhidaeHemiscorpiidaeand ScorpionidaeSignificant morbidity and mortality are caused by scorpion stings In addition to local effectslikerednesspainburningand swellingscorpion venom exhibits variability among sub species and has a complex structure made up of neurotoxic proteinssaltsacidic proteinsand organic compoundsThese components can cause neurologicalcardiovascularhematologicand renal side effectsBecause scorpion venoms are complex mixtures of several toxinsincluding cardiotoxinsnephrotoxinshemolytictoxinsand neurotoxinsthere is a possible danger of developing severe and frequently deadly clinical consequencesHeart failure and pulmonary edema are the main causes of mortality As regards management of scorpion sting early antivenom treatment is recommended but its value remains controversial as it may cause anaphylactic reactions Furthermore the majority of cases need supportive treatment to alleviate the cardiovascular effectCardiovascular symptoms respond well to vasodilators such as alpha-1blockers like prazosinPrazosinis considered a physiological and pharmacological antidote to scorpion venom actionIt antagonizes the after-effects of venom-liberated catecholaminesSince the use of prazosin with antivenom the recovery from scorpion sting has been hastened and mortality rate has been reduced from 30 to 1Uptill now there are no guidlines implemented at our hospital for the management of scorpion sting so that our study will aim at implementing guidelines for management of children with scorpion sting and observe the outcome of those childrenThe guidelines used are those recommended from the Egyptian ministry of health and Population with the addition of prazosin as many studies have concluded the benefits of prazosin
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None