Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06617117
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-25
Brief Title:
Central Vs Brachial BP Exercise and Coronary Artery Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Dynamic Acute Responses of Different Intensity-dependent Exercises on the Autonomic and Vascular Systems in People with Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High blood pressure BP is a major risk factor for coronary artery disease CAD with 30-70 of CAD patients having elevated BP The conventional method of measuring BP in the arm brachial BP may miss some cases as individuals can have normal brachial pressure but elevated central systolic pressure which is a more critical predictor of cardiovascular events Lowering BP is a key objective in cardiac rehabilitation programs
Examining BP responses after a single bout of exercise could help predict how effectively exercise lowers BP over time There is a well-established reduction in BP known as post-exercise hypotension PEH which occurs after exercise This drop is typically around 8 to 9 mmHg and is observed in individuals with and without hypertension However it may not occur in people with CAD The reason for this difference is unclear but may relate to individual variability in exercise responses
No research has closely examined individual responses to PEH in people with CAD and it remains unclear whether exercise affects central and brachial BP differently as some medications do Additionally exercise intensity may influence the magnitude of the BP reduction post-exercise Higher-intensity exercise tends to cause a more significant BP drop both in hypertensive and non-hypertensive individuals typically within 20 to 60 minutes post-exercise
Therefore the present study aimed to determine the acute effects of combined exercise at different intensities on central and brachial blood pressure in individuals with and without coronary artery disease
The key research questions were
1 Is the BP response of central and brachial arteries to acute combined exercise similar How does coronary artery disease influence these BP responses Is there individual variability among people with CAD
2 Does high-intensity exercise compared to moderate-intensity exercise produce more pronounced changes in BP in the post-acute exercise period
All participants were asked to
Complete two combined exercise sessions - one moderate- and one high-intensity bout The order of the sessions was randomly assigned similar to flipping a coin
BP was measured before and after each acute exercise bout in the laboratory The researchers compared central and brachial BP responses between exercise intensities high vs moderate and populations individuals with and without CAD
Examining BP responses after a single bout of exercise could help predict how effectively exercise lowers BP over time There is a well-established reduction in BP known as post-exercise hypotension PEH which occurs after exercise This drop is typically around 8 to 9 mmHg and is observed in individuals with and without hypertension However it may not occur in people with CAD The reason for this difference is unclear but may relate to individual variability in exercise responses
No research has closely examined individual responses to PEH in people with CAD and it remains unclear whether exercise affects central and brachial BP differently as some medications do Additionally exercise intensity may influence the magnitude of the BP reduction post-exercise Higher-intensity exercise tends to cause a more significant BP drop both in hypertensive and non-hypertensive individuals typically within 20 to 60 minutes post-exercise
Therefore the present study aimed to determine the acute effects of combined exercise at different intensities on central and brachial blood pressure in individuals with and without coronary artery disease
The key research questions were
1 Is the BP response of central and brachial arteries to acute combined exercise similar How does coronary artery disease influence these BP responses Is there individual variability among people with CAD
2 Does high-intensity exercise compared to moderate-intensity exercise produce more pronounced changes in BP in the post-acute exercise period
All participants were asked to
Complete two combined exercise sessions - one moderate- and one high-intensity bout The order of the sessions was randomly assigned similar to flipping a coin
BP was measured before and after each acute exercise bout in the laboratory The researchers compared central and brachial BP responses between exercise intensities high vs moderate and populations individuals with and without CAD
Detailed Description:
This study was designed as a randomized cross-over repeated measures experiment All participants underwent two combined exercise sessions of varying intensities specifically high HIGH and moderate MOD in a randomized sequence httpwwwrandomizerorg Before the exercise sessions all participants underwent both cardiopulmonary exercise testing and 1RM testing followed by a DEXA scan during a subsequent visit to the laboratory Each participant completed all experimental sessions consistently at the same time of the day specifically in the mornings with at least 48h between sessions to reduce diurnal variation Post-exercise measurements were conducted at 5 15 and 30 min after exercise Participants reported to the laboratory in a fasted state 4h and refrained from vigorous exercise vitamin supplements and foodsbeverages containing caffeine and alcohol for at least 12 h preceding each experimental session
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None