Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06620081
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-06
Brief Title:
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates A Pilot Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates A Pilot Study
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study evaluated patients on the national lung transplant waiting list It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a treadmill The main findings indicate that the distance covered in the six-minute walk test was greater when using the high-flow nasal cannula supplementation The improvement in exercise performance in this group is associated with a reduction in arterial carbon dioxide optimization of hydrogen potential and a decrease in dynamic hyperinflation leading to fewer symptoms of dyspnea
Detailed Description:
Introduction Pulmonary diseases have a significant global prevalence and lung transplantation is indicated for advanced cases Rehabilitation is essential for patients on the waiting list and requires ventilatory devices for symptom control during exertion The high-flow nasal cannula is a promising alternative but its effects on exercise outcomes are uncertain Objectives To assess the effects of high-flow nasal cannula on the outcomes of the six-minute walk test Method A randomized crossover clinical trial evaluated ten volunteers listed on the national lung transplant waiting list Three functional tests were performed the six-minute walk test incremental lower limb test with arterial blood gas analysis and lower limb endurance test with inspiratory capacity measurement Each test was conducted on different days with different devices high-flow nasal cannula and conventional oxygen therapy totaling six test days The inspired oxygen fraction was titrated to maintain normoxia between 90 to 96 and was kept constant for both interfaces
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None