Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06620484
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-06
Brief Title:
Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluation of muscle state in rheumatoid arthritis patients Application of elastography in the detection of muscle stiffness in rheumatoid arthritis
Detailed Description:
Rheumatoid arthritis is a chronic debilitating disease Muscle weakness is a common symptom in patients with rheumatoid arthritis RA From a metabolic perspective muscle mass is determined by the balance between protein synthesis and degradation People with RA note tenderness stiffness and pain in affected muscles
In RA chronic inflammation is a primary driver of muscle weakness Persistent synovitis leads to the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha TNF-α and interleukin-6 IL-6 which contribute to muscle atrophy and dysfunction Joint damage and pain further limit physical activity exacerbating muscle wasting through disuse atrophy Additionally the systemic inflammation associated with RA can lead to metabolic disturbances including insulin resistance which negatively impacts muscle protein synthesis and overall muscle health
RA can cause a 25 to 70 reduction in muscular strength typically caused by decreased skeletal muscle mass Reduced muscle strength is usually considered to be a result of decreased muscle mass due to disuse atrophy Rheumatoid cachexia a term used in RA is defined as a loss of skeletal muscle mass and with no or little weight loss in fat mass Muscle weakness not only reduces the quality of life for the affected patients but since patientsamp39 ability to work decreases it will also dramatically increase the burden on society eg increased costs for long-term sick leave Thus RA severely affects both the individual and the society Given the complexity of muscle affection in RA accurate assessment is essential for effective management Conventional clinical methods such as manual muscle testing and grip strength measurements provide limited information on the underlying causes of muscle weakness Advanced imaging techniques such as conventional ultrasound US and shear wave elastography SWE offer a more comprehensive evaluation by providing detailed information on muscle morphology and stiffness
In RA chronic inflammation is a primary driver of muscle weakness Persistent synovitis leads to the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha TNF-α and interleukin-6 IL-6 which contribute to muscle atrophy and dysfunction Joint damage and pain further limit physical activity exacerbating muscle wasting through disuse atrophy Additionally the systemic inflammation associated with RA can lead to metabolic disturbances including insulin resistance which negatively impacts muscle protein synthesis and overall muscle health
RA can cause a 25 to 70 reduction in muscular strength typically caused by decreased skeletal muscle mass Reduced muscle strength is usually considered to be a result of decreased muscle mass due to disuse atrophy Rheumatoid cachexia a term used in RA is defined as a loss of skeletal muscle mass and with no or little weight loss in fat mass Muscle weakness not only reduces the quality of life for the affected patients but since patientsamp39 ability to work decreases it will also dramatically increase the burden on society eg increased costs for long-term sick leave Thus RA severely affects both the individual and the society Given the complexity of muscle affection in RA accurate assessment is essential for effective management Conventional clinical methods such as manual muscle testing and grip strength measurements provide limited information on the underlying causes of muscle weakness Advanced imaging techniques such as conventional ultrasound US and shear wave elastography SWE offer a more comprehensive evaluation by providing detailed information on muscle morphology and stiffness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None