Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06620679
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-24
Brief Title:
Mapping the Effect of neuroinflammation on Stress Sensitivity in the Brain of Healthy Men
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Mapping the Effect of neuroinflammation on Stress Sensitivity in the Brain of Healthy Men
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
INFLAMES
Brief Summary:
The goal of this interventional study is to determine the effects of inflammation on stress responses in the brain of healthy men In order to achieve this goal participants are injected with an inflammation-inducing agent then observed inside a brain scanner
Detailed Description:
This interventional study is a randomized triple-blind placebo-controlled cross-over study aiming to elucidate the impact of acute laboratory-induced inflammation using lipopolysaccharide LPS on stress responses in the brain of healthy men Acute stress responses to a psychological task the Maastricht Imaging Stress Task MIST are observed via blood-oxygenation-level-dependent functional magnetic resonance imaging BOLD fMRI and simultaneous positron emission tomography PET imaging using the radiotracer 18 Fluor 18F-NN-diethyl-2-4-2-fluoroethoxyphenyl-57-dimethylpyrazole15-apyrimidine-3-acetamide DPA-714 which targets the 18 kilodalton kDA translocator protein TSPO of activated microglia Every participant will receive 04 ngkg body weight of LPS and saline on separate treatment visits separated by a 2-3 months wash-out period
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None