Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06620991
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-29
Brief Title:
Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery
Detailed Description:
Functional endoscopic sinus surgery FESS is becoming a widely performed operation Its introduction associated with enhanced illumination and visualization has dramatically improved surgical dissection However major complications have been reported for FESS under general anesthesia resulting from impaired visibility due to excessive bleeding
Esmolol is a selective β1-adrenoreceptor antagonist involved in the control of heart rate HR contractility and atrioventricular conduction Currently the use of β-blockade for hemodynamic stability and cardiac protection is well accepted among anesthesia providers but recently researchers have begun to explore the perioperative use of esmolol as an anesthetic adjunct Esmolol was found to produce desired hypotension without tachycardia and improved surgical condition by reducing operative field bleeding
Phentolamine is well known selective α1-blocker which is used to treat hypertensive emergency by producing profound vasodilatation The reduced blood pressure will induce response in the arterial baroreceptors leading to release of adrenal catecholamine eventually inducing reflex tachycardia The reflex tachycardia is less profound in the selective α1-blockers such as phentolamine Phentolamine is a short acting drug with a context sensitive half-life of 15 minutes which makes it ideal for rapid control of blood pressure
Esmolol is a selective β1-adrenoreceptor antagonist involved in the control of heart rate HR contractility and atrioventricular conduction Currently the use of β-blockade for hemodynamic stability and cardiac protection is well accepted among anesthesia providers but recently researchers have begun to explore the perioperative use of esmolol as an anesthetic adjunct Esmolol was found to produce desired hypotension without tachycardia and improved surgical condition by reducing operative field bleeding
Phentolamine is well known selective α1-blocker which is used to treat hypertensive emergency by producing profound vasodilatation The reduced blood pressure will induce response in the arterial baroreceptors leading to release of adrenal catecholamine eventually inducing reflex tachycardia The reflex tachycardia is less profound in the selective α1-blockers such as phentolamine Phentolamine is a short acting drug with a context sensitive half-life of 15 minutes which makes it ideal for rapid control of blood pressure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None