Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06621069
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-24
Brief Title:
The Effect of Long-term Use of Bisphosphonates on Femur Morphology
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Long-term Use of Bisphosphonates on Femur Morphology
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Recent studies have shown that bone modeling can occur throughout life suggesting bone has a persistent ability of adapting structure to loading Some bone medications have a significant effect on the process of bone modeling based on histological studies Bisphosphonates BP a classical anti-resorption drug which impacts the process of bone turnover is related with atypical femur fractures while the mechanism is unclear Several hypotheses are considered competitive Among them increased femur bowing is associated with atypical femoral fractures However it remains doubtful whether long-term BP use increases femur bowing Thus the investigators design this retrospective cohort study
Detailed Description:
If the participants meet the Inclusion Criteria the investigators will collect the baseline characteristics of patients including age gender body mass index BMI as well as characteristics of BMD by dual-energy X-ray absorptiometry DXA BP treatment type of drugs duration before baseline The primary outcome was femoral lateral bowing FLB femoral neck shaft angle FNSA and hip knee shaft angle HKSA from the frontal plane in standing radiographs of the lower limbs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None