Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06621862
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-28
Brief Title:
Clinical Findings and Albuminuria as Predictors of Acute Kidney Injury in Patients With Acute Heart Failure
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical Findings and Albuminuria as Predictors of Acute Kidney Injury in Patients With Acute Heart Failure
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
assess the predictive value of clinical examination and proteinuria as early measures for acute kidney injury AKI in patient with acute heart failure and assessing their prognostic value as measures for mortality during hospital stay
Detailed Description:
Heart failure HF is a chronic and progressive clinical syndrome induced by structural or functional cardiac abnormalities displaying either reduced in HF with reduced ejection fraction HFrEF or preserved in HF with preserved ejection fraction HFpEF left ventricular ejection fraction LVEF 1
Current guidelines define the acute decompensated heart failure ADHF syndrome as the presence of new or worsening signs and symptoms of HF that often lead to hospitalization or an emergency department visit for intensification of therapies 2-4 Due to population growth and ageing the total number of HF patients continues to rise It is estimated that 643 million people live with HF worldwide In developed countries the prevalence of known HF is generally estimated at 1-2 of the general adult population3 5
Acute kidney injury AKI is a frequently occurring complication of critical illness with severe impact on morbidity and mortality Many studies focus on advanced measures such as biomarkers or imaging for predicting AKI These techniques are frequently time-consuming costly and are not available on a global scale In contrast variables obtained by clinical examination are readily available without limitations by set- tings or costs Clinical examination signs and symptoms may reflect the underlying disease state and could therefore potentially be used to identify patients at risk for AKI In addition a few studies have specifically focused on the role of albuminuria in predicting adverse outcomes in heart failure patients
Current guidelines define the acute decompensated heart failure ADHF syndrome as the presence of new or worsening signs and symptoms of HF that often lead to hospitalization or an emergency department visit for intensification of therapies 2-4 Due to population growth and ageing the total number of HF patients continues to rise It is estimated that 643 million people live with HF worldwide In developed countries the prevalence of known HF is generally estimated at 1-2 of the general adult population3 5
Acute kidney injury AKI is a frequently occurring complication of critical illness with severe impact on morbidity and mortality Many studies focus on advanced measures such as biomarkers or imaging for predicting AKI These techniques are frequently time-consuming costly and are not available on a global scale In contrast variables obtained by clinical examination are readily available without limitations by set- tings or costs Clinical examination signs and symptoms may reflect the underlying disease state and could therefore potentially be used to identify patients at risk for AKI In addition a few studies have specifically focused on the role of albuminuria in predicting adverse outcomes in heart failure patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None