Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06626646
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-02
Brief Title:
Vascular Regenerative Cell Exhaustion in Adults with Peripheral Artery Disease PAD-VRCE
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Vascular Regenerative Cell Exhaustion in Adults with Peripheral Artery Disease
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PAD-VRCE
Brief Summary:
PAD-VRCE is an observational cross-sectional two arm study aimed at determining if the presence of peripheral artery disease PAD can influence the number of circulating regenerative cells in blood From peripheral blood samples circulating progenitor cell content will be assessed via flow cytometry and compared between individuals with PAD and individuals without PAD Ultimately this study plans to evaluate the relationship between PAD vascular regenerative cell exhaustion and overall cardiovascular health
Detailed Description:
Individuals with peripheral artery disease PAD have been shown to have poorer cardiovascular health outcomes than the general population It is believed that the number of people living with PAD is greatly underestimated and furthermore mortality due to the most severe form of PAD - critical limb ischemia - is increasing There is a growing body of evidence that the presence of cardiovascular risk factors leads to the imbalance of circulating regenerative cells The aggregate impact of this regenerative cell exhaustion phenotype is an increased risk of adverse events and progression of disease states
PAD-VRCE is an observational cross-sectional two-arm cohort study aimed at determining the differences in the progenitor cell profiles in the blood of individuals with PAD in comparison to individuals without PAD We hypothesize that people with PAD will exhibit depleted levels of these progenitor cells defined as vascular regenerative cell exhaustion VRCE impacts the function of anti-inflammatory cells and associated repair mechanisms within blood vessels and may contribute to the differential long term outcomes between the two groups
PAD-VRCE is an observational cross-sectional two-arm cohort study aimed at determining the differences in the progenitor cell profiles in the blood of individuals with PAD in comparison to individuals without PAD We hypothesize that people with PAD will exhibit depleted levels of these progenitor cells defined as vascular regenerative cell exhaustion VRCE impacts the function of anti-inflammatory cells and associated repair mechanisms within blood vessels and may contribute to the differential long term outcomes between the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None