Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06626906
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-26
Brief Title:
Predictive Value of Sleep Apnea-specific PTT Response for Incident Subclinical Abnormalities in LV Structure and Function in Cohort of moderate-to Severe OSA
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Predictive Value of Sleep Apnea-specific Pulse Transit Time Response for Incident Subclinical Abnormalities in Left Ventricle Structure and Function in Cohort of moderate-to Severe Obstructive Sleep Apnea
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This observational study aims to provide evidence for identifying those who mostly suffer from LV injury and will help construct an optimal strategy for clinical practice The main question it aims to answer is
Could acute PTT response surrounding obstructive respiratory events predict the incidence of subclinical abnormalities in LV structure and function in moderate-to-severe OSA patients Participants who had undergone standard polysomnography and were diagnosed with moderate-to-severe OSA 5 years ago were required to complete the cardiac remodeling and function evaluation
Could acute PTT response surrounding obstructive respiratory events predict the incidence of subclinical abnormalities in LV structure and function in moderate-to-severe OSA patients Participants who had undergone standard polysomnography and were diagnosed with moderate-to-severe OSA 5 years ago were required to complete the cardiac remodeling and function evaluation
Detailed Description:
Obstructive sleep apnea OSA is a widely prevalent medical condition characterized by recurrent upper airway obstruction with intermittent hypoxia sleep disruption and increased ventilation Serial studies have shown that OSA promotes oxidative stress sympathetic activity and intrathoracic pressure fluctuation resulting in adverse cardiac structures and function The cumulative data from observational studies have linked the apnea-hypopnea index AHI an indicator of OSA severity with increased LV injury As OSA is a highly heterogeneous disorder with diverse pathways to disease expression of disease susceptibility to co-morbidities and response to therapy Hence OSA is ideally suited to precision medicine approaches While the current assessment relies on the AHI this traditional metric poorly reflects the complex pathophysiological of OSA on cardiac injury
Asymptotic cardiac dysfunction is not easily identified and many sufferers remain undiagnosed in clinical practice Focusing on recognition and treatment of subclinical cardiac injury early is a potentially powerful strategy to prevent progression to clinical or symptomatic heart failure In OSA patients the BP and heart rate HR changes occurring with obstructive events involve an initial decrease early in the event a gradual increase during the terminal portion of the event and an immediate surgeon resumption of ventilation These acute hemodynamic and autonomic changes may be closely associated with the development and progression of cardiovascular disease Whether this OSA-specific cardiovascular reactivity pattern is the potentially early warning indicator of cardiac injury is unknown
A physiologic parameter termed pulse transit time PTT has been studied intensively as an indirect marker for variations in cardiovascular-related reactivity It can be generally referred to as the time difference for a pulse wave to travel between two arterial sites The speed at which this arterial pressure wave travels was used to assess nocturnal blood pressure variation arterial stiffness changes autonomic nervous response and inspiratory effort More experimentally focused investigations with PTT as a key measure in cardiovascular-related studies are being reported
In the present study the investigators examined acute PTT changes surrounding obstructive events for PTT can be easily measured in standard polysomnography PSG The investigators hypothesized that the specific respiratory events PTT response would predict incident subclinical abnormalities in LV structure and function in a cohort of moderate-to-severe OSA without other confounded morbidities The results of this study provide evidence for identifying those who mostly suffer from LV injury and will help construct an optimal strategy for clinical practice
Asymptotic cardiac dysfunction is not easily identified and many sufferers remain undiagnosed in clinical practice Focusing on recognition and treatment of subclinical cardiac injury early is a potentially powerful strategy to prevent progression to clinical or symptomatic heart failure In OSA patients the BP and heart rate HR changes occurring with obstructive events involve an initial decrease early in the event a gradual increase during the terminal portion of the event and an immediate surgeon resumption of ventilation These acute hemodynamic and autonomic changes may be closely associated with the development and progression of cardiovascular disease Whether this OSA-specific cardiovascular reactivity pattern is the potentially early warning indicator of cardiac injury is unknown
A physiologic parameter termed pulse transit time PTT has been studied intensively as an indirect marker for variations in cardiovascular-related reactivity It can be generally referred to as the time difference for a pulse wave to travel between two arterial sites The speed at which this arterial pressure wave travels was used to assess nocturnal blood pressure variation arterial stiffness changes autonomic nervous response and inspiratory effort More experimentally focused investigations with PTT as a key measure in cardiovascular-related studies are being reported
In the present study the investigators examined acute PTT changes surrounding obstructive events for PTT can be easily measured in standard polysomnography PSG The investigators hypothesized that the specific respiratory events PTT response would predict incident subclinical abnormalities in LV structure and function in a cohort of moderate-to-severe OSA without other confounded morbidities The results of this study provide evidence for identifying those who mostly suffer from LV injury and will help construct an optimal strategy for clinical practice
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None