Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06628154
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-30
Brief Title:
Losartan and Emotional Learning
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effects of Single-dose Losartan on Cognitive Flexibility and Learning in Healthy Adults a Randomised Controlled Study
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study explores the effects of single-dose losartan 50mg versus placebo on emotional processing in healthy volunteers
Detailed Description:
The renin-angiotensin system is a major hormone system involved in blood pressure regulation However its major receptors are also found in the brain particularly in areas implicated in anxiety and depression In line with this topography drugs blocking angiotensin-II receptors have been shown to have effects on cognition that are opposite to those seen in emotional disorders For instance angiotensin receptor blockade improves fear extinction and it dampens stress responsivity to highly aversive images In line with such cognitive effects population-based studies suggest that angiotensin receptor blockers - compared to other antihypertensive drugs - prevent the development of post-traumatic stress disorder following trauma exposition and improve outcomes in patients taking SSRI
This study aims to shed further light on how the renin-angiotensin system affects different aspects of cognitive processing in humans relevant to emotional disorders In a double-blind randomized between-group design we will investigate the effects of a single dose of losartan 50mg versus placebo on emotional processing in N60 healthy volunteers aged 18-50 years Results from this study will help us understand how the renin-angiotensin system affects emotional processing in humans and they will help us identify potential synergistic overlaps with the cognitive mechanisms of action of effective treatment of emotional disorders
This study aims to shed further light on how the renin-angiotensin system affects different aspects of cognitive processing in humans relevant to emotional disorders In a double-blind randomized between-group design we will investigate the effects of a single dose of losartan 50mg versus placebo on emotional processing in N60 healthy volunteers aged 18-50 years Results from this study will help us understand how the renin-angiotensin system affects emotional processing in humans and they will help us identify potential synergistic overlaps with the cognitive mechanisms of action of effective treatment of emotional disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None