Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06629636
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-02
Brief Title:
Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures
Detailed Description:
Reproductive aging is an irreversible process characterized by a decline in oocyte quality posing a significant challenge to fertility and often leading to unsuccessful outcomes in assisted reproductive technologies Repeated ART failures can result in substantial burdens for patients both financially and emotionally Extensive clinical and preclinical data have established a strong correlation between age-related decline in egg quality and mitochondrial deterioration resulting in decreased energy production within oocytes Notably a reduction in nicotinamide adenine dinucleotide NAD NADH concentrations a crucial redox cofactor and enzyme-substrate essential for energy metabolism DNA repair and epigenetic homeostasis has been observed in various tissues with age
Recent studies on mice have indicated that Nicotinamide mononucleotide supplementation may mitigate the age-related decline in NADPH levels enhancing the quality of aged oocytes This improvement is achieved by promoting both nuclear and cytoplasmic maturation ensuring euploidy and fertilization competence ultimately leading to an increased ovulation rate and improved fertility Moreover NMN has been shown to restore mitochondrial function in aged oocytes effectively suppressing the accumulation of reactive oxygen species and DNA damage and subsequently reducing apoptosis
Clinical studies have further corroborated the safety and tolerability of NMN supplementation with daily oral doses of up to 900 mg demonstrating an increase in blood NAD concentrations Furthermore research suggests that a daily oral dose of 900 mg maximizes clinical efficacy as evidenced by blood NAD concentration and physical performance
This study adopts a triple-blind randomized placebo-controlled prospective pilot study design This prospective study aims to evaluate the effects of dietary supplementation with 900mg of NMN on ART outcomes in individuals experiencing in vitro fertilization failures attributed to compromised oocyte and embryo quality
Recent studies on mice have indicated that Nicotinamide mononucleotide supplementation may mitigate the age-related decline in NADPH levels enhancing the quality of aged oocytes This improvement is achieved by promoting both nuclear and cytoplasmic maturation ensuring euploidy and fertilization competence ultimately leading to an increased ovulation rate and improved fertility Moreover NMN has been shown to restore mitochondrial function in aged oocytes effectively suppressing the accumulation of reactive oxygen species and DNA damage and subsequently reducing apoptosis
Clinical studies have further corroborated the safety and tolerability of NMN supplementation with daily oral doses of up to 900 mg demonstrating an increase in blood NAD concentrations Furthermore research suggests that a daily oral dose of 900 mg maximizes clinical efficacy as evidenced by blood NAD concentration and physical performance
This study adopts a triple-blind randomized placebo-controlled prospective pilot study design This prospective study aims to evaluate the effects of dietary supplementation with 900mg of NMN on ART outcomes in individuals experiencing in vitro fertilization failures attributed to compromised oocyte and embryo quality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None