Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06632080
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-06
Brief Title:
Effects of Substance P on Headache Induction in Healthy Individuals
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Substance P on Headache Induction in Healthy Individuals a Randomized Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Substance P is a signaling molecule that has been implicated in the pathogenesis of headache This study aims to ascertain whether administration of substance P can induce headache in healthy adults
Detailed Description:
Substance P is a vasoactive signaling molecule that belongs to the tachykinin family of peptides It is expressed in multiple cells including primary afferents of the trigeminal ganglion that innervate the meninges and its arteries The best-known function of substance P is its role in pain transmission and several lines of evidence has implicated substance P in the pathogenesis of headache This study aims to ascertain whether intravenous infusion of substance P induces headache in healthy individuals who have no past or current history of primary or secondary headache disorder except for infrequent episodic tension-type headache For this purpose we will conduct a randomized double-blind placebo-controlled 2-way crossover trial
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None