Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06633198
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-04
Brief Title:
Heat Microvascular Function and Aging
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Heat Microvascular Function and Aging
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vascular dysfunction is a common factor in many chronic debilitating diseases contributing to morbidity and mortality With the onset of chronic disease or exposure to stress the vasculature displays an inability to adequately respond to increased blood flow demands manifesting in a reduced ability or altered mechanism of vasodilation Aging is an independent risk factor in the development of cardiovascular disease and reduces vasodilator capacity or alters the mechanism by which vasodilation occurs in multiple vascular beds Chronic exercisephysical activity is one of the most potent ways to enhance vascular function resulting in favorable outcomes such as reductions in blood pressure and improved ability to perform activities of daily living Barriers to exercise or failure of long-term adherence preclude many populations from the cardiovascular benefits of exercise thus further enhancing cardiovascular risk Avenues to mimic blood flow patterns observed with exercise may exert beneficial effects without the need for the ability to exercise Recent evidence has demonstrated that passive heat therapy or chronic heat exposure 1C in core temperature results in reductions in major adverse cardiovascular events blood pressure and improved large artery endothelial function primarily through preservation of large artery function in response to vascular stress It is unclear whether microvascular function is augmented in response to acute heat exposure or whether this can protect against vascular insults particularly in older adults Some preliminary evidence in humans suggest that autophagy a cell recycling process is involved in the beneficial cardiovascular effects as short-term heat exposure upregulates markers of autophagy Previous evidence from our lab indicates that autophagy governs the mechanism by which microvascular vasodilation occurs The role of autophagy in mediating the beneficial effects of passive heating is unknown
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None