Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06634498
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-05
Brief Title:
The Effect of Repetitive Transcranial Magnetic Stimulation for Internet Gaming Disorder
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex in Internet Gaming Disorder
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the intervention effects of navigated repetitive transcranial magnetic stimulation rTMS on craving regulation in individuals with internet gaming disorder IGD The primary objectives include 1 examining the impact of navigated rTMS over the dorsolateral prefrontal cortex DLPFC on the gaming cravings and craving regulation capacity and 2 exploring the potential neural mechanisms by which rTMS over the DLPFC improves craving intensity and craving regulation ability
Detailed Description:
Repetitive transcranial magnetic stimulation rTMS has been shown to reduce cravings in individuals with substance addiction However to date no studies have systematically examined the short-term and long-term clinical and cognitive effects of sustained rTMS treatment on internet gaming disorder IGD This study seeks to fill that gap by adopting a within-subject design to investigate the cognitive craving regulation capacity and neural structural changes resting-state and task-related brain activity and functional connectivity between the dorsolateral prefrontal cortex DLPFC and reward-related brain regions effects of personalized and precisely navigated rTMS treatment in individuals with IGD
Participants will receive both real intermittent theta-burst stimulation iTBS and sham stimulation targeting the left DLPFC The study aims to assess how these interventions influence clinical and neural outcomes Specifically the experiment will measure changes in craving regulation capacity and neural markers including resting-state functional connectivity and task-evoked activation patterns in key brain regions associated with addiction such as the DLPFC and reward system
The entire experimental protocol spans three weeks and follows a randomized crossover design Participants will be randomly assigned to one of two intervention sequences real iTBS followed by sham stimulation or sham stimulation followed by real iTBS Each rTMS session will utilize iTBS parameters lasting approximately 10 minutes with a minimum of one week between the two sessions to avoid potential carryover effects
To evaluate the effects of the interventions clinical assessments Craving scores cognitive measures craving regulation ability and neuroimaging data fMRI at rest and during task performance will be collected after each intervention session This approach allows for a comprehensive assessment of both the short-term and potential cumulative effects of rTMS on cognitive and neural correlates of IGD contributing valuable insights into the mechanisms by which rTMS may modulate addictive behaviors and associated neural circuits
Participants will receive both real intermittent theta-burst stimulation iTBS and sham stimulation targeting the left DLPFC The study aims to assess how these interventions influence clinical and neural outcomes Specifically the experiment will measure changes in craving regulation capacity and neural markers including resting-state functional connectivity and task-evoked activation patterns in key brain regions associated with addiction such as the DLPFC and reward system
The entire experimental protocol spans three weeks and follows a randomized crossover design Participants will be randomly assigned to one of two intervention sequences real iTBS followed by sham stimulation or sham stimulation followed by real iTBS Each rTMS session will utilize iTBS parameters lasting approximately 10 minutes with a minimum of one week between the two sessions to avoid potential carryover effects
To evaluate the effects of the interventions clinical assessments Craving scores cognitive measures craving regulation ability and neuroimaging data fMRI at rest and during task performance will be collected after each intervention session This approach allows for a comprehensive assessment of both the short-term and potential cumulative effects of rTMS on cognitive and neural correlates of IGD contributing valuable insights into the mechanisms by which rTMS may modulate addictive behaviors and associated neural circuits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None