Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06635590
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-08
Brief Title:
Chronic Kidney Disease Hyperkalemia and Echocardiographic Changes
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Impact of Hyperkalemia-Induced ECG and ECHO Findings on Early and Late Mortality in Patients With Chronic Kidney Disease
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with CKD eGFR lt lt60 mLmin173 m2 presenting to emergency department with isolated hyperkalemia will be study population Pre and post treatment ECG and echocardiographic findings will be recorded Investigator will not intervene with the treatment decision of responsible physician and will not delay any intervetion or treatment for the sake of study
Data will be compared in terms of ECHO and ECG findings depending on hyperkalemia level and response to treatment
Data will be compared in terms of ECHO and ECG findings depending on hyperkalemia level and response to treatment
Detailed Description:
In this study the ECG and echocardiography ECHO findings in patients with chronic kidney failure who present to the Etlik City Hospital Emergency Medicine Department will be recorded and compared with literature Echocardiography is a rapid reliable and non-invasive examination widely used by physicians for the monitoring of critically ill patients in emergency departments and intensive care units worldwide
For patients with known chronic kidney failure brought to the emergency department a blood sample blood gas andor biochemistry will be taken for potassium measurement Subsequently an ECG which is a quick and non-invasive test will be performed followed by an ECHO also a quick and non-invasive test conducted by an experienced physician The physician performing the ECHO will not be involved in the treatment process ECG and ECHO findings will be recorded and compared before and after treatment Patient mortality will be monitored at 24 hours 7 days and 30 days and other causes of mortality will be excluded The relationship between ECG and ECHO findings and mortality will be statistically investigated
Based on the premise that hyperkalemia can cause cardiac arrest during diastole it is hypothesized that there may be right ventricular enlargement in patients with ECG findings indicative of hyperkalemia In animal studies echocardiography results during resuscitation have shown right ventricular enlargement in animals with hyperkalemia Based on this information we believe that echocardiography findings in hyperkalemic patients may be associated with mortality and that the combined use of echocardiography and ECG may be effective in predicting mortality
For patients with known chronic kidney failure brought to the emergency department a blood sample blood gas andor biochemistry will be taken for potassium measurement Subsequently an ECG which is a quick and non-invasive test will be performed followed by an ECHO also a quick and non-invasive test conducted by an experienced physician The physician performing the ECHO will not be involved in the treatment process ECG and ECHO findings will be recorded and compared before and after treatment Patient mortality will be monitored at 24 hours 7 days and 30 days and other causes of mortality will be excluded The relationship between ECG and ECHO findings and mortality will be statistically investigated
Based on the premise that hyperkalemia can cause cardiac arrest during diastole it is hypothesized that there may be right ventricular enlargement in patients with ECG findings indicative of hyperkalemia In animal studies echocardiography results during resuscitation have shown right ventricular enlargement in animals with hyperkalemia Based on this information we believe that echocardiography findings in hyperkalemic patients may be associated with mortality and that the combined use of echocardiography and ECG may be effective in predicting mortality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None