Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06636201
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-25
Brief Title:
Large-scale Multi-omics Analysis of Cerebrospinal Fluid
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Deputy Director of Department of Neurosurgery the Second Affiliated Hospital of Zhejiang University School of MedicineProfessor
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to explore the role of cerebrospinal fluid CSF biomarkers in aging and neurodegenerative diseases
Detailed Description:
This study aims to investigate the role of cerebrospinal fluid CSF biomarkers in aging and neurodegenerative diseases with a focus on the following objectives
Analysis of Age-Related Changes in CSF Biomarkers The study will analyze CSF samples from different age groups to identify biomarkers that undergo significant changes during the aging process This includes the investigation of amyloid-beta Aβ42 Tau proteins including the phosphorylated form p-tau181 and other proteins related to neuroinflammation and blood-brain barrier function
Development of a Predictive Model for Early Diagnosis By categorizing and quantifying CSF proteins across various age groups the study aims to establish a predictive model for the early diagnosis of neurodegenerative diseases such as Alzheimers disease The ability to detect these diseases before clinical symptoms emerge could enable early intervention and treatment offering a crucial window for therapeutic strategies
Investigation of Dynamic Changes in CSF Biomarkers Across Disease Stages The study will examine the dynamic changes in CSF biomarkers at different stages of neurodegenerative diseases including early middle and late stages Understanding the role of these biomarkers in disease progression will provide insights into the pathological processes and potential therapeutic windows
Creation of a Comprehensive CSF Biomarker Database A database will be established encompassing CSF biomarkers from various age groups disease states and treatment responses This resource will be invaluable for future research facilitating the scientific communitys understanding of neurodegenerative diseases and the development of new therapeutic approaches
Through the achievement of these objectives this study aims to advance the application of CSF biomarkers in neuroscience research and clinical practice ultimately improving the diagnosis management and treatment of aging-related and neurodegenerative conditions
Analysis of Age-Related Changes in CSF Biomarkers The study will analyze CSF samples from different age groups to identify biomarkers that undergo significant changes during the aging process This includes the investigation of amyloid-beta Aβ42 Tau proteins including the phosphorylated form p-tau181 and other proteins related to neuroinflammation and blood-brain barrier function
Development of a Predictive Model for Early Diagnosis By categorizing and quantifying CSF proteins across various age groups the study aims to establish a predictive model for the early diagnosis of neurodegenerative diseases such as Alzheimers disease The ability to detect these diseases before clinical symptoms emerge could enable early intervention and treatment offering a crucial window for therapeutic strategies
Investigation of Dynamic Changes in CSF Biomarkers Across Disease Stages The study will examine the dynamic changes in CSF biomarkers at different stages of neurodegenerative diseases including early middle and late stages Understanding the role of these biomarkers in disease progression will provide insights into the pathological processes and potential therapeutic windows
Creation of a Comprehensive CSF Biomarker Database A database will be established encompassing CSF biomarkers from various age groups disease states and treatment responses This resource will be invaluable for future research facilitating the scientific communitys understanding of neurodegenerative diseases and the development of new therapeutic approaches
Through the achievement of these objectives this study aims to advance the application of CSF biomarkers in neuroscience research and clinical practice ultimately improving the diagnosis management and treatment of aging-related and neurodegenerative conditions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None