Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06636747
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-08
Brief Title:
High Resolution Diffusion Weighted Imaging in Prostate
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Comparative Study of High Resolution DWI and Conventional DWI in Prostate
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
hrDWI might be an alternative to cDWI for the prostate imaging
1 increase the signal-to-noise ratio and contrast-to-noise ratio yielding high-fidelity images with less noise in general
2 improve the diagnostic accuracy of PCa in particular than conventional DWI
1 increase the signal-to-noise ratio and contrast-to-noise ratio yielding high-fidelity images with less noise in general
2 improve the diagnostic accuracy of PCa in particular than conventional DWI
Detailed Description:
Magnetic Resonance Imaging MRI with the Prostate Imaging Reporting and Data System PI-RADS is a state-of-the-art strategy not only for standardizing prostate MRI scanning but also for PCa detection diagnosis and staging In PI-RADS score evaluation diffusion weighted imaging DWI is an important component of the prostate MRI examination which is considered to be the dominant sequence for the assessment of lesions in the peripheral zone PZ and is also regarded as the auxiliary sequence for the upgrade of lesions in the transitional zone TZ DWI reflects the random motion of water molecules that should include high b-value images at least b1400smm² and an calculated ADC map As the b-value increases DWI enables detection of small changes because of better contrast between malignant and background tissue Meanwhile the problems arise DWI is often plagued by poor spatial resolution distortion and artifacts as well as decreased signal-to-noise ratio SNR and contrast-to-noise ratio CNR This is a major obstacle to the application interpretation and ultimate impact of prostate MRI Improving the quality of DWI images would be helpful in lesion orientation and detection of small cancersRecently a novel denoising technique that operating on repetitively acquired MRI data and only removing components that cannot be distinguished from zero-mean Gaussian distributed noise has been proposed for acquisition of ultra-high resolution images Recent studies have shown that ultra-high resolution images significantly improvements in temporal-SNR the detection and reproducibility of stimulus-induced signal changes and the accuracy of images Based on reconstruction algorithms with trainable components high resolution DWI hrDWI can increase the SNR and CNR yielding high-fidelity images with less noise in general and thus to improve the diagnostic accuracy of PCa in particular than conventional DWI cDWITherefore we made the hypothesis that hrDWI might be an alternative to cDWI for the prostate imaging The purpose of this study includes two aspects 1 compare objective and subjective image quality and lesion conspicuity of hrDWI with cDWI in prostate MRI 2 test the non-inferiority of hrDWI in terms of PCa diagnosis against cDWI in a cohort of suspcious patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None