Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06636994
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-09
Brief Title:
Anatomical and Functional Predictions of Blindsight Abilities in Patients With Homonymous Lateral Hemianopsia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Anatomical and Functional Predictions of Blindsight Abilities in Patients With Homonymous Lateral Hemianopsia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PRE-SIGHT
Brief Summary:
Homonymous lateral hemianopia HLH is characterized by loss of vision in half the visual field and is the most common neurovisual disorder following stroke
Numerous behavioral and neuroanatomical studies have focused on the phenomenon of blindsight corresponding to patients unconscious residual visual capacities in the blind hemifield Cohort studies of patients have highlighted different types of blindsight and a low occurrence of the phenomenon initially described 1 type 1 blindsight 12 unconscious visual abilities 2 type 2 blindsight visual abilities associated with sensations in the blind field 18 3 blindsense sensations in the blind field without visual abilities 30 and 4 no blindsight 40 The heterogeneity of these blindsight abilities in the HLH population is closely related to patients neuroanatomical and functional profiles
In particular resting-state functional imaging r-fMRI and default mode network analysis have highlighted a significant correlation between the degree of inter-hemispheric connection between the healthy and injured hemispheres and the rate of spontaneous visual field recovery To our knowledge this degree of functional connectivity has not yet been studied in relation to blindsight abilities However this functional MRI measurement tool represents a potential predictive factor for patients residual performance in their blindsight field in order to assess the level of visuo-cognitive impairment and ultimately to adapt care
Numerous behavioral and neuroanatomical studies have focused on the phenomenon of blindsight corresponding to patients unconscious residual visual capacities in the blind hemifield Cohort studies of patients have highlighted different types of blindsight and a low occurrence of the phenomenon initially described 1 type 1 blindsight 12 unconscious visual abilities 2 type 2 blindsight visual abilities associated with sensations in the blind field 18 3 blindsense sensations in the blind field without visual abilities 30 and 4 no blindsight 40 The heterogeneity of these blindsight abilities in the HLH population is closely related to patients neuroanatomical and functional profiles
In particular resting-state functional imaging r-fMRI and default mode network analysis have highlighted a significant correlation between the degree of inter-hemispheric connection between the healthy and injured hemispheres and the rate of spontaneous visual field recovery To our knowledge this degree of functional connectivity has not yet been studied in relation to blindsight abilities However this functional MRI measurement tool represents a potential predictive factor for patients residual performance in their blindsight field in order to assess the level of visuo-cognitive impairment and ultimately to adapt care
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None