Viewing Study NCT06637748



Ignite Creation Date: 2024-10-26 @ 3:42 PM
Last Modification Date: 2024-10-26 @ 3:42 PM
Study NCT ID: NCT06637748
Status: NOT_YET_RECRUITING
Last Update Posted: None
First Post: 2024-10-08

Brief Title: Echo and Electrocardiographic Findings in Children With Bronchial Asthma At Sohag University Hospital
Sponsor: None
Organization: None

Study Overview

Official Title: Echo and Electrocardiographic Findings in Children With Bronchial Asthma At Sohag University Hospital
Status: NOT_YET_RECRUITING
Status Verified Date: 2024-10
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: No
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Bronchial asthma is a common respiratory disorder among children worldwide Asthma is characterized by chronic inflammation and remodeling of the airways induced by recurrent exposure to hypoxemia that leads to repeated tissue injury and repair The interaction between respiratory diseases and cardiovascular function is complex Cardiac dysfunction can be attributed to pulmonary hypertension PH secondary to recurrent hypoxia in patients with bronchial asthma PH affects the pulmonary vasculature by releasing various cytokines leading to pulmonary vasoconstriction and enhancing the remodeling process with muscularization and proliferation of the vascular media and intima Other hypotheses concluded that the exaggerated respiratory efforts may raise the intrathoracic pressure and increase right ventricle RV afterload and consequently RV hypertrophy andor dilatation Children with severe bronchial asthma can experience cor pulmonale later in life but little is known about the early cardiac changes that might be present during childhood especially for mild or moderate persistent asthma Some studies have reported right ventricular dysfunction as the earliest hemodynamic change among those cases Other studies did not report these results and reported impaired systolic function of the left ventricle LV even before diastolic dysfunction Insufficient control of BA in turn can cause the formation of various pathological conditions For example there are studies showing the risk of cardiac arrhythmias and conduction disorders in patients with uncontrolled BA due to functional changes or pathological remodeling of the myocardium Atrial remodeling which is the pathomorphological basis of serious supraventricular cardiac arrhythmias has a more rapid progression with poor BA control and is formed as a result of excessive stretching of the atrial wall as well as other adverse factors The connection between BA and supraventricular arrhythmias including atrial fibrillation AF was noted in studies by Cepelis et al Available data indicate that in the adult population cardiac arrhythmias are significantly more common in patients with BA than in those without it 9 The results of a Norwegian population study HUNT study demonstrate that the risks of supraventricular arrhythmias and AF are increased in patients with an uncontrolled BA Electrocardiography ECG is the universal screening method for assessing the state of the atrial myocardium and the conducting system of the heart According to German et al ECG analysis can make a significant input to the assessment of the risk of formation of supraventricular rhythm and conduction disorders Therefore the analysis of the atrial component of the ECG and atrioventricular conduction in patients with BA is an important component of the management of these patients especially in pediatric practice Consequently the study of the characteristics of the ECG and its supraventricular component in children with BA is relevan
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None