Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06640634
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-08
Brief Title:
Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache Results of Two Randomized Sham - Controlled Trials
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Post-dural puncture headache PDPH is the most prevalent complication in patients undergoing diagnostic or therapeutic lumbar puncture LP The pathophysiology of PDPH is primarily attributed to the mechanical traction on pain-sensitive intracranial nerves eg the upper cervical 5th 9th and 10th cranial nerves and vascular structures mediated by persistent dural damage leading to cerebrospinal fluid CSF leakage and subsequent CSF pressure reduction
According to the International Classification of Headache Disorders 3rd edition ICHD3 PDPH is classified as a headache subtype due to low CSF pressure It typically manifests as an orthostatic headache within a few days post-LP accompanied by symptoms such as neck pain tinnitus auditory changes photophobia and nausea While PDPH usually resolves within 7-10 days it can result in extended hospital stays and increased need for medication The use of atraumatic needles is the most effective preventive measure for PDPH though other commonly recommended practices such as bed rest fluid administration and caffeine have questionable efficacy
Transcranial direct current stimulation tDCS is a non-invasive brain stimulation NIBS technique that applies low-voltage electrical currents through surface electrodes on the scalp Depending on the stimulation type-anodal or cathodal-tDCS can induce long-lasting increases or decreases in neuronal excitability and vascular-neuronal activity coupling Research has shown that anodal tDCS a-tDCS applied to the primary motor cortex M1 can alleviate various pain conditions including fibromyalgia neuropathic pain and headaches The pain-relieving effects of M1 a-tDCS are believed to follow the modulation of intracortical inhibitory GABAergic transmission and the descending connections from M1 to the thalamus and periaqueductal gray
Although short-term a-tDCS treatment has shown promise in preventing migraines and medication-overuse headaches its role in preventing and treating PDPH remains unexplored This study aims to evaluate the efficacy of preventive and therapeutic a-tDCS applied to M1 in patients undergoing diagnostic LP
According to the International Classification of Headache Disorders 3rd edition ICHD3 PDPH is classified as a headache subtype due to low CSF pressure It typically manifests as an orthostatic headache within a few days post-LP accompanied by symptoms such as neck pain tinnitus auditory changes photophobia and nausea While PDPH usually resolves within 7-10 days it can result in extended hospital stays and increased need for medication The use of atraumatic needles is the most effective preventive measure for PDPH though other commonly recommended practices such as bed rest fluid administration and caffeine have questionable efficacy
Transcranial direct current stimulation tDCS is a non-invasive brain stimulation NIBS technique that applies low-voltage electrical currents through surface electrodes on the scalp Depending on the stimulation type-anodal or cathodal-tDCS can induce long-lasting increases or decreases in neuronal excitability and vascular-neuronal activity coupling Research has shown that anodal tDCS a-tDCS applied to the primary motor cortex M1 can alleviate various pain conditions including fibromyalgia neuropathic pain and headaches The pain-relieving effects of M1 a-tDCS are believed to follow the modulation of intracortical inhibitory GABAergic transmission and the descending connections from M1 to the thalamus and periaqueductal gray
Although short-term a-tDCS treatment has shown promise in preventing migraines and medication-overuse headaches its role in preventing and treating PDPH remains unexplored This study aims to evaluate the efficacy of preventive and therapeutic a-tDCS applied to M1 in patients undergoing diagnostic LP
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None