Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06642259
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-18
Brief Title:
Correlation Between Triglyceride Glucose Index and Residual SYNTAX Score in STEMI Patients Undergoing PPCI
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Correlation Between Triglyceride Glucose Index and Residual SYNTAX Score in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study To check correlation between triglyceride glucose TyG index and residual SYNTAX score RSS in STEMI patients undergoing PPCI
2 Impact of both TyG index and RSS in STEMI patients undergoing PPCI on LV EF recovery after 3 months using LV speckle tracking
3 Impact of RSS and TyG index in STEMI patients undergoing PPCI on short term MACE at 3 months duration
2 Impact of both TyG index and RSS in STEMI patients undergoing PPCI on LV EF recovery after 3 months using LV speckle tracking
3 Impact of RSS and TyG index in STEMI patients undergoing PPCI on short term MACE at 3 months duration
Detailed Description:
ST-elevation myocardial infarction STEMI is known as a life-threatening complication of coronary artery disease CAD and it is one of the leading causes of death all over the world Primary percutaneous coronary intervention PPCI of the culprit vessel in patients with STEMI is standard clinical practice
At the time of PPCI 40-65 of the patients exhibit one or more concomitant coronary lesions ie multivessel disease MVD The presence of narrowed coronaries other than those related to index ischemia in patients with STEMI is suggested as a feature associated with adverse clinical outcomes
The recently developed residual SYNTAX Score RSS developed 2012 and validated in 2013 is an objective quantitative measure of the degree and complexity of residual stenosis after percutaneous coronary intervention PCI It was developed to quantitatively assess the degree and complexity of residual stenoses based on recalculating the SYNTAX score from coronary angiography after PCI Higher RSS has been associated with worse outcome in patients undergoing angiography-mediated PCI
Insulin resistance IR is an important risk factor for the development of CAD It is defined as a state in which a greater than normal amount of insulin is required to elicit a quantitatively normal response
Previous studies have shown an independent association between IR and CVD IR is tightly associated with increased cardiovascular morbidity and mortality by adversely modifying well-established cardiovascular risk factors such as dyslipidemia and hypertension and by causing endothelial dysfunction
At the time of PPCI 40-65 of the patients exhibit one or more concomitant coronary lesions ie multivessel disease MVD The presence of narrowed coronaries other than those related to index ischemia in patients with STEMI is suggested as a feature associated with adverse clinical outcomes
The recently developed residual SYNTAX Score RSS developed 2012 and validated in 2013 is an objective quantitative measure of the degree and complexity of residual stenosis after percutaneous coronary intervention PCI It was developed to quantitatively assess the degree and complexity of residual stenoses based on recalculating the SYNTAX score from coronary angiography after PCI Higher RSS has been associated with worse outcome in patients undergoing angiography-mediated PCI
Insulin resistance IR is an important risk factor for the development of CAD It is defined as a state in which a greater than normal amount of insulin is required to elicit a quantitatively normal response
Previous studies have shown an independent association between IR and CVD IR is tightly associated with increased cardiovascular morbidity and mortality by adversely modifying well-established cardiovascular risk factors such as dyslipidemia and hypertension and by causing endothelial dysfunction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None