Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06645743
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-11
Brief Title:
Retrospective Analysis of Clinical and CT Features to Predict Spread Through Air Space in Stage IA Lung Adenocarcinoma
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical and Imaging Features Were Used to Predict the Occurrence of Spread Through Air Space in Stage IA Lung Adenocarcinoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to provide a basis for the selection of surgical methods for patients with stage IA lung adenocarcinoma Air cavity dissemination is a poor prognostic factor for patients with stage IA lung adenocarcinoma We retrospectively collected clinical and imaging data of stage IA lung adenocarcinoma patients Independent risk factors associated with spread through air space in stage IA lung adenocarcinoma patients were analyzed so as to predict the occurrence of spread through air space and provide basis for the selection of surgical methods
Detailed Description:
Referring from Global Cancer Report 2020 lung cancer remains the leading cause of tumor death with adenocarcinoma as the primary histological subtype In 2021 the World Health Organization WHO proposed a new classification standard for lung cancer dividing adenocarcinomas into in-situ adenocarcinomas microinvasive adenocarcinomas and invasive adenocarcinomas based on their invasive development
Due to the widespread popularization of early screening for lung cancer a growing number of IA lung adenocarcinomas cases manifesting as lung nodules have been detected and surgical resection remains the most critical treatment options for such individuals With the emergence of relevant research results sublobectomy has become a preferred method for early stage IA lung adenocarcinoma However some individuals with lung adenocarcinoma in stage IA undergoing sublobectomy still have recurrence and metastasis in which spread through air spaces STAS plays vital role
STAS was formally proposed by WHO in 2015 as a new invasion mode of invasive lung adenocarcinoma STAS is characterized by pathological micropapillary clusters solid nests or isolated cells located beyond the tumor margin counting one or more infiltrating the air spaces within the surrounding lung parenchyma and detached from the primary tumor rather than forming distinct tumor islands A number of studies have pointed out that STAS is associated with poor prognosis of patients many researchers continue to favor lobectomy when treating patients with stage IA lung adenocarcinoma exhibiting positive STAS
Due to the limitations of intraoperative frozen section in predicting STAS preoperative application of clinical and imaging features in predicting STAS shows great advantages Former research has suggested that clinical and imaging characteristics can predict occurrence of STAS despite the difference of results from different studies Onozato et al believe that smokers are more likely to develop STAS which is consistent with the study by Shiono et al However Uruga et albelieved that the occurrence of STAS was unrelated to smoking Warth et al believed that male lung adenocarcinoma patients were more prone to STAS while Kadota stated the occurrence of STAS was unrelated to patient gender
However the sample size included in these previous studies is small and the parameters included by various scholars are different and there is still a lack of large sample studies systematically analyzing clinical and imaging characteristics to predict the spread through air space of stage IA lung adenocarcinoma Therefore we plan to carry out this study Based on a large sample size the clinical and imaging characteristics of patients with stage IA lung adenocarcinoma were comprehensively analyzed to predict the spread through air space so as to provide a reference for the selection of surgical methods
Due to the widespread popularization of early screening for lung cancer a growing number of IA lung adenocarcinomas cases manifesting as lung nodules have been detected and surgical resection remains the most critical treatment options for such individuals With the emergence of relevant research results sublobectomy has become a preferred method for early stage IA lung adenocarcinoma However some individuals with lung adenocarcinoma in stage IA undergoing sublobectomy still have recurrence and metastasis in which spread through air spaces STAS plays vital role
STAS was formally proposed by WHO in 2015 as a new invasion mode of invasive lung adenocarcinoma STAS is characterized by pathological micropapillary clusters solid nests or isolated cells located beyond the tumor margin counting one or more infiltrating the air spaces within the surrounding lung parenchyma and detached from the primary tumor rather than forming distinct tumor islands A number of studies have pointed out that STAS is associated with poor prognosis of patients many researchers continue to favor lobectomy when treating patients with stage IA lung adenocarcinoma exhibiting positive STAS
Due to the limitations of intraoperative frozen section in predicting STAS preoperative application of clinical and imaging features in predicting STAS shows great advantages Former research has suggested that clinical and imaging characteristics can predict occurrence of STAS despite the difference of results from different studies Onozato et al believe that smokers are more likely to develop STAS which is consistent with the study by Shiono et al However Uruga et albelieved that the occurrence of STAS was unrelated to smoking Warth et al believed that male lung adenocarcinoma patients were more prone to STAS while Kadota stated the occurrence of STAS was unrelated to patient gender
However the sample size included in these previous studies is small and the parameters included by various scholars are different and there is still a lack of large sample studies systematically analyzing clinical and imaging characteristics to predict the spread through air space of stage IA lung adenocarcinoma Therefore we plan to carry out this study Based on a large sample size the clinical and imaging characteristics of patients with stage IA lung adenocarcinoma were comprehensively analyzed to predict the spread through air space so as to provide a reference for the selection of surgical methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None