Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06648577
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-10
Brief Title:
3D Ultrasound Myocardial Mechanical Wave Measurements
Sponsor:
None
Organization:
None
Study Overview
Official Title:
3D Ultrasound Myocardial Mechanical Wave Measurements in Primary Mitral Regurgitation
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
3DUsMR
Brief Summary:
Primary mitral regurgitation MR is a frequent disease that can ultimately lead to heart failure Primary MR represents the second most prevalent cause of cardiac valve surgery in high income countries Progressive myocardial fibrosis due to chronic volume overload is recognized as a pathophysiological substrate of altered LV function in primary MR As fibrosis leads to increased myocardial stiffness ultrasound mechanical wave propagation measurements within the myocardium could provide important clinical information Natural mechanical wave velocity MWV imaging using High-frame-rate HFR echocardiography has emerged as a promising tool to evaluate myocardial stiffness
The objective is study is to evaluate the correlation between the LV myocardial stiffness as assessed by 3D ultrasound myocardial MWV mapping and myocardial interstitial fibrosis as measured using CMR myocardial extracellular volume measure
The objective is study is to evaluate the correlation between the LV myocardial stiffness as assessed by 3D ultrasound myocardial MWV mapping and myocardial interstitial fibrosis as measured using CMR myocardial extracellular volume measure
Detailed Description:
After being informed about the study All patients giving written informed consent will undergo in a routine practice
1 echocardiography 2D3D
2 CMR imaging
3 electrocardiogram 24 hours monitoring
4 blood sampling including brain natriuretic peptide measurement
5 symptom-limited combined exercise echocardiography and oxygen uptake measurements
1 echocardiography 2D3D
2 CMR imaging
3 electrocardiogram 24 hours monitoring
4 blood sampling including brain natriuretic peptide measurement
5 symptom-limited combined exercise echocardiography and oxygen uptake measurements
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None