Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06651372
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-17
Brief Title:
The Interest of Systematic Screening for Dengue Chikungunya and Zika in Malaria-negative Return Travelers
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Interest of Systematic Screening for Dengue Chikungunya and Zika in Patients for Whom a Malaria Diagnosis is Negative in the Event of a Recent Return From Travel a Retrospective Study at the University Hospitals of Strasbourg 2024-2025
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
International travel has increased dramatically in recent years Vector-borne pathologies such as malaria and arboviruses are common etiologies of post-travel fever which are prevalent in similar geographical areas tropical and intertropical Arboviruses for arthropod-borne viruses are transmitted by the bite of blood-sucking vectors mosquitoes ticks or sandflies The dengue chikungunya and zika viruses are transmitted through the bite of an infected Aedes mosquito Aedes aegypti and Aedes albopictus
The establishment of Aedes albopictus tiger mosquito competent for transmitting these 3 viruses since 2004 in mainland France and the transit of travelers carrying a virus allowed the appearance of the first autochthonous cases of dengue and zika Each year outbreaks of autochthonous cases of dengue fever are reported in the PACA Occitanie and Auvergne-Rhône Alpes regions and a cluster of 3 Indigenous cases was reported in 2023 in the Paris region
Since 2014 the tiger mosquito has been established in Bas-Rhin Between 2014 and 2022 the vector was detected in around thirty municipalities around Strasbourg In a department where the spread of the tiger mosquito is evolving rapidly these data remind us that only an early diagnosis delivered quickly allows effective vector control measures to avoid generating autochthonous transmission
In a previous study carried out at the Virology laboratory we retrospectively analyzed the diagnosis of these 3 arboviruses after the exclusion of malaria in the context of recent travel over a period of 10 years 2014-2023 Among the 913 patients included for 78 of cases n714 no testing for dengue chikungunya or zika was carried out a proportion stable over 10 years
These three arboviruses seem underdiagnosed and we assume given our previous results that 8 to 10 of patients for whom in the context of recent travel a test for malaria comes back negative are imported cases of dengue chikungunya or zika At the end of this retrospective study we want to evaluate this sub-diagnosis on a larger sample to propose a review of practices and the establishment of Arbovirus-malaria reflex testing Currently no French or similar European data is available allowing us to evaluate this under-diagnosis which constitutes a significant risk of the emergence of indigenous clusters in our territory
The main objective of this study is to determine the infection rate by dengue chikungunya and zika viruses identified when the diagnosis is made after the exclusion of negative malaria in the context of recent travel among patients treated at the Strasbourg University Hospitals between January 1 2024 and December 31 2025
The secondary objectives of this work are as follows
Estimate the prevalence of different clinical symptoms patient medical records in retrospectively identified cases of dengue chikungunya and zika
Evaluate the onset time of symptoms in relation to the date of returnarrival from the area of stay of retrospectively identified cases of dengue chikungunya and zika
Evaluate the delay in the appearance of symptoms in relation to the date of taking the initial sample the one leading to the diagnosis of negative malaria of retrospectively identified cases of dengue chikungunya and zika
Study the laboratory results associated with the initial management of the patient biochemical assessment and blood count of retrospectively identified cases of dengue chikungunya and zika
Study the distribution of areas periods and reasons for staying in retrospectively identified dengue chikungunya and zika cases
Study the municipalities of residence of positive cases in the areas where the tiger mosquito is established
The establishment of Aedes albopictus tiger mosquito competent for transmitting these 3 viruses since 2004 in mainland France and the transit of travelers carrying a virus allowed the appearance of the first autochthonous cases of dengue and zika Each year outbreaks of autochthonous cases of dengue fever are reported in the PACA Occitanie and Auvergne-Rhône Alpes regions and a cluster of 3 Indigenous cases was reported in 2023 in the Paris region
Since 2014 the tiger mosquito has been established in Bas-Rhin Between 2014 and 2022 the vector was detected in around thirty municipalities around Strasbourg In a department where the spread of the tiger mosquito is evolving rapidly these data remind us that only an early diagnosis delivered quickly allows effective vector control measures to avoid generating autochthonous transmission
In a previous study carried out at the Virology laboratory we retrospectively analyzed the diagnosis of these 3 arboviruses after the exclusion of malaria in the context of recent travel over a period of 10 years 2014-2023 Among the 913 patients included for 78 of cases n714 no testing for dengue chikungunya or zika was carried out a proportion stable over 10 years
These three arboviruses seem underdiagnosed and we assume given our previous results that 8 to 10 of patients for whom in the context of recent travel a test for malaria comes back negative are imported cases of dengue chikungunya or zika At the end of this retrospective study we want to evaluate this sub-diagnosis on a larger sample to propose a review of practices and the establishment of Arbovirus-malaria reflex testing Currently no French or similar European data is available allowing us to evaluate this under-diagnosis which constitutes a significant risk of the emergence of indigenous clusters in our territory
The main objective of this study is to determine the infection rate by dengue chikungunya and zika viruses identified when the diagnosis is made after the exclusion of negative malaria in the context of recent travel among patients treated at the Strasbourg University Hospitals between January 1 2024 and December 31 2025
The secondary objectives of this work are as follows
Estimate the prevalence of different clinical symptoms patient medical records in retrospectively identified cases of dengue chikungunya and zika
Evaluate the onset time of symptoms in relation to the date of returnarrival from the area of stay of retrospectively identified cases of dengue chikungunya and zika
Evaluate the delay in the appearance of symptoms in relation to the date of taking the initial sample the one leading to the diagnosis of negative malaria of retrospectively identified cases of dengue chikungunya and zika
Study the laboratory results associated with the initial management of the patient biochemical assessment and blood count of retrospectively identified cases of dengue chikungunya and zika
Study the distribution of areas periods and reasons for staying in retrospectively identified dengue chikungunya and zika cases
Study the municipalities of residence of positive cases in the areas where the tiger mosquito is established
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None